Journal ArticleDOI
Clastogenic evaluation of cathinone and amphetamine in somatic cells of mice.
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Results substantiate earlier observations on the clastogenic and mitodepressive activity of cathinone on the meristematic region of Allium cepa and indicate that cathin one may be responsible for the mutagenic effect of khat reported by other workers.About:
This article is published in Mutation Research Letters.The article was published on 1987-02-01. It has received 39 citations till now. The article focuses on the topics: Cathinone & Khat.read more
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Journal ArticleDOI
The in vivo micronucleus assay in mammalian bone marrow and peripheral blood. A report of the U.S. Environmental Protection Agency Gene-Tox Program
TL;DR: The protocol recommended for the micronucleus assay in mammalian bone marrow has been revised and simplified and the minimum number of cells to be scored per treatment group has been increased to 20,000 to increase the ability of the assay to detect a doubling of the control micron nucleus frequency.
Journal ArticleDOI
A core in vitro genotoxicity battery comprising the Ames test plus the in vitro micronucleus test is sufficient to detect rodent carcinogens and in vivo genotoxins.
TL;DR: There is no convincing evidence that any genotoxic rodent carcinogens or in vivo genotoxins would remain undetected in an in vitro test battery consisting of Ames+MNvit.
Journal ArticleDOI
The potential adverse effects of habitual use of Catha edulis (khat)
TL;DR: Administration of Catha edulis extracts showed a deranged systemic capacity to handle oxidative radicals and induces cytotoxic effects in cells of liver and kidney, as well as induction of cell death in various human leukaemia cell lines and in peripheral human blood leukocytes.
Journal ArticleDOI
Khat (Catha edulis) consumption causes genotoxic effects in humans.
TL;DR: Results suggest that khat consumption, especially when accompanied by alcohol and tobacco consumption, might be a potential cause of oral malignancy.
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Habitual risk factors for head and neck cancer.
David M. Goldenberg,Juna Lee,Wayne M. Koch,Michael M. Kim,Barry Trink,David Sidransky,Chul So Moon +6 more
TL;DR: Habitual and social risk factors for cancer of the head and neck, excluding smoking and alcohol consumption are reviewed.
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Journal Article
The chemistry of khat.
TL;DR: Cathinone is the main phenylalkylamine component of fresh khat, and pharmacological studies indicate that it may be the compound responsible for the characteristic stimulant activity and abuse potential of the plant.
Journal ArticleDOI
A current assessment of the mutagenic and teratogenic effects of caffeine.
Philip S. Thayer,Paul E. Palm +1 more
TL;DR: An attempt is made to draw pertinent data from the experimental studies of mutagenesis and teratogenesis, in conjunction with studies of caffeine metabolism and distribution in mammalian organisms including man, and to interrelate these factors in terms of mechanism of action and pharmacokinetics.