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Clinical Evaluation of Moro (Citrus Sinensis (L.) Osbeck) Orange Juice Supplementation for the Weight Management

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TLDR
It could be suggested that the active compounds contained in Moro Juice have a synergistic effect on fat accumulation in humans and Moro juice extract can be used in weight management and in the prevention of human obesity.
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This article is published in Natural Product Research.The article was published on 2015-01-15 and is currently open access. It has received 56 citations till now. The article focuses on the topics: Orange juice & Citrus × sinensis.

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Chemistry and Pharmacology of Citrus sinensis.

TL;DR: The therapeutic potential of C. sinensis is revealed as a source of natural compounds with important activities that are beneficial for human health that could be used to develop new drugs.
Journal ArticleDOI

Antiobesity Effects of Anthocyanins in Preclinical and Clinical Studies.

TL;DR: This review focused on current knowledge about anthocyanins' role in obesity and its related comorbidities reported in animal models and humans and summarized their target identification and mechanism of action through several pathways and their final effects on health and well-being.
Journal ArticleDOI

Citrus fruits and their flavonoids in inflammatory bowel disease: an overview.

TL;DR: The aim of the present review is to provide robust evidence favouring their role in the prevention and treatment of IBD, as well as to lay the foundations for further studies in human with the aim of evaluating the concrete applicability of Citrus fruits and their flavonoids.
Journal ArticleDOI

Protective Effects of Anthocyanins in Obesity‐Associated Inflammation and Changes in Gut Microbiome

TL;DR: This review summarizes the reported benefits of anthocyanins in obesity-associated inflammation, and underlying molecular mechanisms, including the role of gut microbiome and cell signaling pathways regulated by anthocianins both in vivo and in vitro.
Journal ArticleDOI

Current Evidence to Propose Different Food Supplements for Weight Loss: A Comprehensive Review.

TL;DR: A combination of supplements most supported by current evidence is proposed, that leverages all mechanisms of action possibly leading to a synergistic effect and greater weight loss in the foreseen absence of adverse events.
References
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Journal ArticleDOI

Dietary cyanidin 3-O-beta-D-glucoside-rich purple corn color prevents obesity and ameliorates hyperglycemia in mice.

TL;DR: The results suggest that dietary PCC may ameliorate HF diet-induced insulin resistance in mice and provide a biochemical and nutritional basis for the use of PCC or anthocyanins as a functional food factor that may have benefits for the prevention of obesity and diabetes.
Journal ArticleDOI

Palmitic and linoleic acids induce ER stress and apoptosis in hepatoma cells.

TL;DR: The results suggest that linoleic acid promotes cell apoptosis through the release of cytochrome C, only if the intracellular calcium flux is unperturbed and intact.
Journal ArticleDOI

Anthocyanin enhances adipocytokine secretion and adipocyte-specific gene expression in isolated rat adipocytes.

TL;DR: It is demonstrated that anthocyanins (cyanidin or cyanidin 3-glucoside) have the potency of a unique pharmacological function in isolated rat adipocytes, and the AMP:ATP ratio was significantly decreased by administration of the anthOCyanins.
Journal ArticleDOI

Blood orange juice inhibits fat accumulation in mice.

TL;DR: The findings suggest that multiple components present in the Moro orange juice might act synergistically to inhibit fat accumulation, and that Moro juice anti-obesity effect on fat accumulation cannot be explained only by its anthocyanin content.

ORIGINAL ARTICLE Blood orange juice inhibits fat accumulation in mice

TL;DR: In this article, the effect of the juice obtained from two varieties of sweet oranges (Citrus sinensis L. Osbeck), Moro (a blood orange) and Navelina (a blond orange), on fat accumulation in mice fed a standard or a high-fat diet (HFD) was analyzed.
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Frequently Asked Questions (12)
Q1. What are the contributions mentioned in the paper "Natural product research: formerly natural product letters" ?

In this paper, a randomized clinical trial was carried out to evaluate Moro ( Citrus sinensis ( L. ) Osbeck ) orange juice supplementation for the weight management. 

Conventional managements of overweight and obesity include low-fat diet, exercise, behavioural interventions and pharmacological agents. 

Results obtained from the analysis of the chromatograms showed that the extract contained several citrus class compounds such as anthocyanins, flavone glycosides, hydroxycinnamic acids and ascorbic acid. 

Results obtained in these clinical trials showed that MoroEx intake is able to induce a significant reduction in body weight, BMI, waist and hip circumference in comparison with the non-treated group. 

Other comorbidities include gallbladder disease, fatty liver, sleep apnoea and osteoarthritis with reduced quality of life and life expectancy (Sengupta et al. 2012). 

The typical red coloration of the fruits is attributed to the presence of pigmented compounds called anthocyanins, not usually contained in blond sweet oranges and other citrus fruits. 

Results showed that Moro juice extract intake was able to induce a significant reduction in body mass index (BMI) after 4 weeks of treatment (p , 0.05). 

Previous study carried out on in vitro and in vivomodels has proven that Moro juice intake is able to affect fat accumulation (Titta et al. 2009; Salamone et al. 2012). 

a significant reduction in body weight (BMI) was observed in volunteers treated with MoroEx after 4 weeks of treatment ( p , 0.05). 

On the basis of these interesting results, a randomised, placebo, doubleblinded clinical trial was carried out to evaluate the effects of Moro juice extract intake in decreasing the body weight in human healthy subjects. 

Even if further investigations could be useful to better understand the activity and mechanism of action of Moro juice, results obtained in this study showed that MoroEx supplementation could be considered a natural ingredient useful in the management of overweight and in the prevention of obesity. 

All these findings suggest that Moro juice anti-obesity effect cannot be explained only by anthocyanins as other components contained in Moro orange may act synergistically to inhibit fat accumulation (Titta et al. 2009; Salamone et al. 2012).