Clinicians' response to hyperoxia in ventilated patients in a Dutch ICU depends on the level of FiO2.
TLDR
Hyperoxia is frequently seen but in most cases does not lead to adjustment of ventilator settings if FiO2 <0.41, implementation of guidelines concerning oxygen therapy should be improved and further research is needed concerning the effects of frequently encountered hyperoxia.Abstract:
Purpose
Hyperoxia may induce pulmonary injury and may increase oxidative stress. In this retrospective database study we aimed to evaluate the response to hyperoxia by intensivists in a Dutch academic intensive care unit.read more
Citations
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Journal ArticleDOI
Effect of Conservative vs Conventional Oxygen Therapy on Mortality Among Patients in an Intensive Care Unit: The Oxygen-ICU Randomized Clinical Trial
Massimo Girardis,Stefano Busani,Elisa Damiani,Abele Donati,Laura Rinaldi,Andrea Marudi,Andrea Morelli,Massimo Antonelli,Mervyn Singer +8 more
TL;DR: Among critically ill patients with an ICU length of stay of 72 hours or longer, a conservative protocol for oxygen therapy vs conventional therapy resulted in lower ICU mortality and preliminary findings were based on unplanned early termination of the trial.
Journal ArticleDOI
Arterial hyperoxia and mortality in critically ill patients: a systematic review and meta-analysis
Elisa Damiani,Erica Adrario,Massimo Girardis,Rocco Romano,Paolo Pelaia,Mervyn Singer,Abele Donati +6 more
TL;DR: Hyperoxia may be associated with increased mortality in patients with stroke, traumatic brain injury and those resuscitated from cardiac arrest, but results are limited by significant heterogeneity between studies.
Journal ArticleDOI
Association Between Arterial Hyperoxia and Outcome in Subsets of Critical Illness: A Systematic Review, Meta-Analysis, and Meta-Regression of Cohort Studies.
TL;DR: In various subsets of critically ill patients, arterial hyperoxia was associated with poor hospital outcome, and more evidence is needed to provide optimal oxygen targets to critical care physicians.
Journal ArticleDOI
Conservative versus Liberal Oxygenation Targets for Mechanically Ventilated Patients. A Pilot Multicenter Randomized Controlled Trial
Rakshit Panwar,Miranda Hardie,Rinaldo Bellomo,Loïc Barrot,Glenn M Eastwood,Paul J Young,Gilles Capellier,Gilles Capellier,Peter W J Harrigan,Michael Bailey +9 more
TL;DR: This study supports the feasibility of a conservative oxygenation strategy in patients receiving IMV, and larger randomized controlled trials of this intervention appear justified.
Journal ArticleDOI
Metrics of Arterial Hyperoxia and Associated Outcomes in Critical Care
Hendrik J. F. Helmerhorst,Derk L. Arts,Marcus J. Schultz,Peter H. J. van der Voort,Ameen Abu-Hanna,Evert de Jonge,David J. van Westerloo +6 more
TL;DR: The results suggest that the PaO2 levels of critically ill patients within a safe range, as the authors do with other physiologic variables, should be limited.
References
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TL;DR: The effects of mechanical ventilation on injured lungs and the underlying mechanisms are outlined and modified so that VALI is kept to a minimum improves survival of patients with ARDS.
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TL;DR: No effective pharmacologic means exist for lessening pulmonary oxygen toxicity in humans and the pathologic changes of oxygen toxicity are not specific and resemble those of the adult respiratory distress syndrome.