Clonal Relationships between Invasive and Carriage Streptococcus pneumoniae and Serotype- and Clone-Specific Differences in Invasive Disease Potential
Angela B. Brueggemann,Angela B. Brueggemann,David Griffiths,Emma Meats,Tim E. A. Peto,Derrick W. Crook,Brian G. Spratt +6 more
TLDR
Analysis of isolates of the same genotype, but different serotype, suggested that capsular serotype may be more important than genotype in the ability of pneumococci to cause invasive disease.Abstract:
By use of multilocus sequence typing, Streptococcus pneumoniae isolates causing invasive disease (n=150) were compared with those from nasopharyngeal carriage (n=351) among children in Oxford. The prevalence of individual clones (sequence types) and serotypes among isolates from invasive disease was related to their prevalence in carriage, and an odds ratio (OR) for invasive disease was calculated for the major clones and serotypes. All major carried clones and serotypes caused invasive disease, although their ability to do so varied greatly. Thus, 2 serotype 14 clones were approximately 10-fold overrepresented among disease isolates, compared with carriage isolates, whereas a serotype 3 clone was approximately 10-fold underrepresented. The lack of heterogeneity between the ORs of different clones of the same serotype, and analysis of isolates of the same genotype, but different serotype, suggested that capsular serotype may be more important than genotype in the ability of pneumococci to cause invasive disease.read more
Citations
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Streptococcus pneumoniae colonisation: the key to pneumococcal disease.
TL;DR: The mechanism and epidemiology of colonisation, the complexity of relations within and between species, and the consequences of the different preventive strategies for pneumococcal colonisation are discussed.
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Incidence of Pneumococcal Disease Due to Non-Pneumococcal Conjugate Vaccine (PCV7) Serotypes in the United States during the Era of Widespread PCV7 Vaccination, 1998–2004
Lauri A. Hicks,Lee H. Harrison,Brendan Flannery,James L. Hadler,William Schaffner,Allen S. Craig,Delois Jackson,Ann Thomas,Bernard Beall,Ruth Lynfield,Arthur Reingold,Monica M. Farley,Cynthia G. Whitney +12 more
TL;DR: The incidence of pneumococcal disease caused by nonvaccine serotypes is increasing and Ongoing surveillance is needed to monitor the magnitude of disease cause by non vaccines, to ensure that future vaccines target the appropriate serotypes.
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TL;DR: Multi-locus sequence typing was proposed as a nucleotide sequence-based approach that could be applied to many bacterial pathogens to provide a portable, reproducible, and scalable typing system that reflected the population and evolutionary biology of bacterial pathogens.
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A multilocus sequence typing scheme for Streptococcus pneumoniae: identification of clones associated with serious invasive disease
Mark C. Enright,Brian G. Spratt +1 more
TL;DR: A pneumococcal multilocus sequence typing scheme and database is developed by sequencing approximately 450 bp fragments of seven housekeeping loci from 295 isolates to provide an allelic profile, or sequence type (ST), and the relatedness between isolates was obtained by constructing a dendrogram from the matrix of pairwise differences between STs.
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