Comparative accuracies of two common screening instruments for classification of Alzheimer's disease, mild cognitive impairment, and healthy aging.
David R. Roalf,Paul J. Moberg,Sharon X. Xie,David A. Wolk,Stephen T. Moelter,Steven E. Arnold +5 more
TLDR
The aim of this study was to compare the utility and diagnostic accuracy of the Montreal Cognitive Assessment (MoCA) and Mini‐Mental State Examination (MMSE) in the diagnosis of Alzheimer's disease and mild cognitive impairment in a clinical cohort.Abstract:
Background The aim of this study was to compare the utility and diagnostic accuracy of the Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE) in the diagnosis of Alzheimer's disease (AD) and mild cognitive impairment (MCI) in a clinical cohort. Methods Three hundred twenty-one AD, 126 MCI, and 140 older adults with healthy cognition (HC) were evaluated using the MMSE, the MoCA, a standardized neuropsychologic battery according to the Consortium to Establish a Registry of Alzheimer's Disease (CERAD-NB), and an informant-based measure of functional impairment, the Dementia Severity Rating Scale (DSRS). Diagnostic accuracy and optimal cut-off scores were calculated for each measure, and a method for converting MoCA to MMSE scores is presented. Results The MMSE and MoCA offer reasonably good diagnostic and classification accuracy as compared with the more detailed CERAD-NB; however, as a brief cognitive screening measure, the MoCA was more sensitive and had higher classification accuracy for differentiating MCI from HC. Complementing the MMSE or the MoCA with the DSRS significantly improved diagnostic accuracy. Conclusion The findings support recent data indicating that the MoCA is superior to the MMSE as a global assessment tool, particularly in discerning earlier stages of cognitive decline. In addition, we found that overall diagnostic accuracy improves when the MMSE or MoCA is combined with an informant-based functional measure. Finally, we provide a reliable and easy conversion of MoCA to MMSE scores. However, the need for MCI-specific measures is still needed to increase the diagnostic specificity between AD and MCI.read more
Citations
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The Diagnosis and Management of Mild Cognitive Impairment: A Clinical Review
Kenneth M. Langa,Deborah Levine +1 more
TL;DR: Cognitive decline and MCI have important implications for patients and their families and will require that primary care clinicians be skilled in identifying and managing this common disorder as the number of older adults increases in coming decades.
Journal ArticleDOI
A re-examination of Montreal Cognitive Assessment (MoCA) cutoff scores.
TL;DR: A systematic review and meta‐analysis of the literature was conducted to determine the diagnostic accuracy of the MoCA for differentiating healthy cognitive aging from possible MCI.
Journal ArticleDOI
Relationship between the Montreal Cognitive Assessment and Mini-mental State Examination for assessment of mild cognitive impairment in older adults
TL;DR: MoCA and MMSE were more similar for dementia cases, but MoCA distributes MCI cases across a broader score range with less ceiling effect and functional assessment can help exclude dementia cases.
Journal ArticleDOI
Is the Montreal Cognitive Assessment (MoCA) test better suited than the Mini-Mental State Examination (MMSE) in mild cognitive impairment (MCI) detection among people aged over 60? Meta-analysis.
Natalia Ciesielska,Remigiusz Sokołowski,Ewelina Mazur,Marta Podhorecka,Anna Polak-Szabela,Kornelia Kędziora-Kornatowska +5 more
TL;DR: MoCA test better meets the criteria for screening tests for the detection of MCI among patients over 60 years of age than MMSE, which is claimed to be imprecise for MCI detection.
Journal ArticleDOI
Version 3 of the Alzheimer Disease Centers' Neuropsychological Test Battery in the Uniform Data Set (UDS)
Sandra Weintraub,Lilah M. Besser,Hiroko H. Dodge,Merilee Teylan,Steven H. Ferris,Felicia C. Goldstein,Bruno Giordani,Joel H. Kramer,David A. Loewenstein,Daniel C. Marson,Dan M Mungas,David P. Salmon,Kathleen A. Welsh-Bohmer,Xiao Hua Zhou,Steven D. Shirk,Alireza Atri,Alireza Atri,Walter A. Kukull,Creighton H. Phelps,John C. Morris +19 more
TL;DR: A revision of the neuropsychological battery of the Uniform Data Set, which covers episodic memory, processing speed, executive function, language, and constructional ability, is described.
References
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Journal ArticleDOI
“Mini-mental state”: A practical method for grading the cognitive state of patients for the clinician
Marshal F. Folstein,Marshal F. Folstein,Susan E B Folstein,Susan E B Folstein,Paul R. McHugh,Paul R. McHugh +5 more
TL;DR: A simplified, scored form of the cognitive mental status examination, the “Mini-Mental State” (MMS) which includes eleven questions, requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
A practical method for grading the cognitive state of patients for the clinician
TL;DR: The Mini-Mental State (MMS) as mentioned in this paper is a simplified version of the standard WAIS with eleven questions and requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
Journal ArticleDOI
The Montreal Cognitive Assessment, MoCA: A Brief Screening Tool For Mild Cognitive Impairment
Ziad S. Nasreddine,Natalie A. Phillips,Valérie Bédirian,Simon Charbonneau,Victor Whitehead,Isabelle Collin,Jeffrey L. Cummings,Howard Chertkow +7 more
TL;DR: A 10‐minute cognitive screening tool (Montreal Cognitive Assessment, MoCA) to assist first‐line physicians in detection of mild cognitive impairment (MCI), a clinical state that often progresses to dementia.
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