Comparison of Testosterone Levels in Patients With and Without Type 2 Diabetes.
Naina Kumari,Anoosha Khan,Usman Shaikh,Kimberly Lobes,Deepak Kumar,Fnu Suman,Naila S Bhutto,Faryal Anees,Simra Shahid,Amber Rizwan +9 more
TLDR
In this paper, a case-control survey was conducted from September 2020 to March 2021 in the outpatient department of internal medicine in a tertiary care hospital in Pakistan to highlight the testosterone level in type 2 diabetes mellitus (DM).Abstract:
Introduction Hypogonadotropic hypogonadism is a common disorder associated with type 2 diabetes. Hypogonadotropic hypogonadism in type 2 diabetic patients requires further assessment to understand the etiology, and the possible consequences, complications, and treatment This study aims to highlight the testosterone level in type 2 diabetes mellitus (DM). Moreover, it further emphasizes the association of testosterone with the duration of DM. Materials and method This case-control survey was conducted from September 2020 to March 2021 in the outpatient department of internal medicine in a tertiary care hospital in Pakistan. The experiment group included 200 diabetic male participants aged between 30 and 69 years. In the control group, 200 participants without DM were enrolled in the study. The venous blood sample was collected via phlebotomy and sent to the laboratory to test for total testosterone level. Results The mean total testosterone level was significantly lower in diabetic patients compared to the non-diabetic patients (8.9 ± 5.1 mmol/L vs. 14.1 ± 7.2 mmol/L; p-value: <0.0001) and the prevalence of androgen deficiency was significantly higher in diabetic patients compared to non-diabetic patients (45.5% vs. 20.5%; p-value: <0.00001). For each age group, the mean total testosterone level was significantly higher in the diabetic group compared to the non-diabetic group. There was a significant decline in mean total testosterone level as the duration of diabetes increased (p-value: 0.01). Conclusion Strong interlink between type 2 DM and low testosterone level has once again highlighted the importance of a broader approach toward men presenting in the diabetic clinic and provided a huge ground for prescribing testosterone replacement therapy in hypogonadal men with DM.read more
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Features of steroidogenesis in men with hypogonadism and type 2 diabetes
Roman Viktorovich Rozhivanov,M. O. Chernova,V. A. Ioutsi,Galina A. Melnichenko,Marina Vladimirovna Shestakova,Natalia Mokrysheva +5 more
TL;DR: The prevalence of male hypogonadism in type 2 diabetes, determined by high-precision tandem mass spectrometry, was 69,5%.
Journal ArticleDOI
The incidence and aggravating factors of male hypogonadism in type 2 diabetes
Roman Viktorovich Rozhivanov,M. O. Chernova,Galina A. Melnichenko,Marina Vladimirovna Shestakova,Natalia Mokrysheva +4 more
TL;DR: The prevalence of male hypogonadism in type 2 diabetes was 70,3%, and its development was associated with obesity and poor glycemic control.
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Clinical and epidemiological characteristics of male hypogonadism in type 2 diabetes in Russia: combined analysis of study data for the period 2005–2022
M. O. Chernova,Dmitry I. Esaulenko,E. R. Rozhivanova,Roman Viktorovich Rozhivanov,Galina A. Melnichenko,Marina Vladimirovna Shestakova,Natalia Mokrysheva +6 more
TL;DR: In this article , the authors assessed the clinical and epidemiological characteristics and aggravating factors of male hypogonadism in Type 2 Diabetes mellitus (T2DM) in Russia.
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Higher testosterone is associated with open-angle glaucoma in women: a genetic predisposition?
Joëlle E. Vergroesen,E Aribas,Maryam Kavousi,Joyce B. J. van Meurs,Caroline C W Klaver,Wishal D. Ramdas +5 more
TL;DR: In this paper , the authors evaluated the association of testosterone and its genetic predisposition with open-angle glaucoma (OAG), intraocular pressure (IOP), retinal nerve fiber layer (RNFL), and ganglion cell-inner plexiform layer (GCL+).
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