Comparison of the Antitumor Effect Between Brucine Stealth Liposome and Brucine Conventional Liposome

TLDR: Compared with conventional liposomes, stealth liposome, as the carrier of brucine, can enhance the antitumor effect and obvious immunosup- pressive effect was not found in the brucce stealth lipOSome group.

Abstract: Objective To compare the antitumor effects between brucine stealth liposome and brucine conventional lipo- some.Methods KM mice received inoculation of murine hep2 carcinoma cells (H22).The H22 mice were randomly ad- ministered with brucine solution,brucine conventional liposome or brucine stealth liposome(3.23 mg·kg~(-1),ip) for 8 days.The effectiveness was assessed based on tumor inhibition rate.Meanwhile,the mice body weight and immune organ weight were also compared.Results The brucine solution,brucine conventional liposome and brucine stealth liposome in the same dose showed an inhibition rate of 28.64 %,57.96 % and 71.36 %,respectively.Obvious immunosup- pressive effect was not found in the brucine stealth liposome group.Conclusion Compared with conventional liposome, stealth liposome,as the carrier of brucine,can enhance the antitumor effect.