Complementation analysis of linked circadian clock mutants of Neurospora crassa.
Jerry F. Feldman,Marian Hoyle +1 more
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A fourth mutant of Neurospora crassa, designated frq-4, has been isolated in which the period length of the circadian conidiation rhythm is shortened to 19.3 hours, suggesting that all four mutations are allelic.Abstract:
A fourth mutant of Neurospora crassa, designated frq-4, has been isolated in which the period length of the circadian conidiation rhythm is shortened to 19. +/- 0.3 hours. This mutant is tightly linked to the three previously isolated frq mutants, and all four map to the right arm of linkage group VII about 10 map units from the centromere. Complementation tests suggest, but do not prove, that all four mutations are allelic, since each of the four mutants is co-dominant with the frq+ allel--i.e., heterokaryons have period lengths intermediate between the mutant and wild-type--and since heterokaryons between pairs of mutants also have period lengths intermediate between those of the two mutants.read more
Citations
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Journal ArticleDOI
Chromosomal loci of Neurospora crassa.
Journal ArticleDOI
Genetic analysis of circadian clocks.
TL;DR: This survey has been made somewhat simpler due the series of excellent reviews on clocks that have appeared over the past five years and an increasing interest and appreciation of the strengths of genetics in offering a different set of tools and a different way of thinking about the problems that circadian biologists have been considering for several decades.
Journal ArticleDOI
Loss of Temperature Compensation of Circadian Period Length in the frq-9 Mutant of Neurospora crassa
TL;DR: Since several of the other frq mutants show partial loss in temperature compensation, it is suggested that the frq gene or its product is closely related to the temperature compensation mechanism of the circadian clock of Neurospora.
Journal ArticleDOI
The mouse Clock mutation behaves as an antimorph and maps within the W19H deletion, distal of Kit.
David P. King,Martha Hotz Vitaterna,Anne Marie Chang,William F. Dove,Lawrence H. Pinto,Fred W. Turek,Joseph S. Takahashi +6 more
TL;DR: High-resolution genetic map of the Clock locus is generated and it is reported that Clock is 0.7 cM distal of Kit on mouse chromosome 5, and implementation analysis of different Clock and W19H compound genotypes indicates that the Clock mutation behaves as an antimorph.
Book ChapterDOI
Circadian rhythms in unicellular organisms: an endeavor to explain the molecular mechanism.
TL;DR: This chapter discusses the circadian rhythms in unicellular organisms and the molecular mechanisms of circadian-time measurement, which are among the basic regulatory phenomena in biology whose mechanisms are essentially unknown.
References
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Journal ArticleDOI
Isolation of Circadian Clock Mutants of NEUROSPORA CRASSA
Jerry F. Feldman,Marian Hoyle +1 more
TL;DR: Three mutants of Neurospora crassa have been isolated which have altered period lengths of their circadian rhythm of conidiation, and it is suggested that these mutants represent alterations in the basic timing mechanism of the circadian clock of neurospora.
Journal ArticleDOI
Methionine synthesis in neurospora. the isolation of cystathionine
TL;DR: Among artificially produced biochemical mutants of Neurospora, those which have lost the ability to synthesize methionine form the largest class, and some of the mutants require organically bound sulfur for growth, an indication that in these strains the block in methamphetamineionine synthesis comes at a later stage than sulfate reduction.