Clock Mutants of Drosophila melanogaster
Ronald J. Konopka,Seymour Benzer +1 more
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Three mutants have been isolated in which the normal 24-hour rhythm is drastically changed and all these mutations appear to involve the same functional gene on the X chromosome.Abstract:
Three mutants have been isolated in which the normal 24-hour rhythm is drastically changed. One mutant is arrhythmic; another has a period of 19 hr; a third has a period of 28 hr. Both the eclosion rhythm of a population and the locomotor activity of individual flies are affected. All these mutations appear to involve the same functional gene on the X chromosome.read more
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A Functional Analysis of Circadian Pacemakers in Nocturnal Rodents. I. The Stability and Lability of Spontaneous Frequency
Serge Daan,Colin S. Pittendrigh +1 more
TL;DR: In this paper, a model of non-parametric entrainment of circadian pacemakers is tested for the case of nocturnal rodents using 1 or 2 light pulses per cycle, and the model makes use of the available data on freerunning period (τ) in constant darkness and on phase response curves (PRC) for short light pulses.
Journal ArticleDOI
A functional analysis of circadian pacemakers in nocturnal rodents
Serge Daan,Colin S. Pittendrigh +1 more
TL;DR: In this article, phase response curves for 15′ bright light pulses of four species of nocturnal rodents are described, and the response to a resetting stimulus at a given phase of the rhythm is correlated with the individual's free-running period.
Journal ArticleDOI
Using FlyAtlas to identify better Drosophila melanogaster models of human disease
TL;DR: FlyAtlas provides the most comprehensive view yet of expression in multiple tissues of Drosophila melanogaster, demonstrating the limitations of whole-organism approaches to functional genomics and allowing modeling of a simple tissue fractionation procedure that should improve detection of weak or tissue-specific signals.
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Stability, Precision, and Near-24-Hour Period of the Human Circadian Pacemaker
Charles A. Czeisler,Jeanne F. Duffy,Theresa L. Shanahan,Emery N. Brown,Jude F. Mitchell,D. W. Rimmer,Joseph M. Ronda,Edward J. Silva,James S. Allan,Jonathan S. Emens,Derk-Jan Dijk,Richard E. Kronauer +11 more
TL;DR: In this article, the intrinsic period of the human circadian pacemaker averages 24.18 hours in both age groups, with a tight distribution consistent with other species, with important implications for understanding the pathophysiology of disrupted sleep in older people.
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An hPer2 Phosphorylation Site Mutation in Familial Advanced Sleep Phase Syndrome
Kong L. Toh,Christopher R. Jones,Yan He,Erik J. Eide,William A. Hinz,David M. Virshup,Louis J. Ptáček,Ying-Hui Fu +7 more
TL;DR: A variant in human sleep behavior can be attributed to a missense mutation in a clock component, hPER2, which alters the circadian period.
References
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Circadian Nature of a Rhythm Expressed by an Invertaseless Strain of Neurospora crassa
TL;DR: A new strain of Neurospora crassa which exhibits a rhythm of conidiation when growing along an agar surface in a growth tube is described and is compared to 2 other strains of neurospora which also express a rhythm, patch and clock.
Journal ArticleDOI
Temperature compensation of the circadian oscillation in drosophila pseudoobscura and its entrainment by temperature cycles.
William F. Zimmerman,William F. Zimmerman,Colin S. Pittendrigh,Colin S. Pittendrigh,Theodosius Pavlidis,Theodosius Pavlidis +5 more
TL;DR: An empirical relationship is found between temperature steps and pulses and, to first approximation, the +A+ or - A+ generated by 12 hr pulses may be computed from the A# generated by the steps comprising that pulse, justifying the assumption that the A+ normally effected by the step is accomplished rapidly (within a few hours).