Complete genome sequences of Newcastle disease virus strains circulating in chicken populations of Indonesia.
Sa Xiao,Anandan Paldurai,Baibaswata Nayak,Arthur S. Samuel,Eny E. Bharoto,Teguh Y. Prajitno,Peter L. Collins,Siba K. Samal +7 more
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This is the first report of complete genome sequences of NDV strains isolated from chickens in Indonesia and it classified them into two new subgroups of genotype VII in the class II cluster that were genetically distinct from vaccine strains.Abstract:
Eight highly virulent Newcastle disease virus (NDV) strains were isolated from vaccinated commercial chickens in Indonesia during outbreaks in 2009 and 2010. The complete genome sequences of two NDV strains and the sequences of the surface protein genes (F and HN) of six other strains were determined. Phylogenetic analysis classified them into two new subgroups of genotype VII in the class II cluster that were genetically distinct from vaccine strains. This is the first report of complete genome sequences of NDV strains isolated from chickens in Indonesia.read more
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Temporal, geographic, and host distribution of avian paramyxovirus 1 (Newcastle disease virus).
TL;DR: Information is reviewed on the host, temporal, and geographic distribution of APMV-1 genetic diversity based on the evolutionary systematics of the complete coding region of the fusion gene.
Journal ArticleDOI
Identification of new sub-genotypes of virulent Newcastle disease virus with potential panzootic features
Patti J. Miller,Ruth Haddas,Luba Simanov,Avishay Lublin,Shafqat Fatima Rehmani,Abdul Wajid,Tasra Bibi,Taseer Ahmad Khan,Tahir Yaqub,Surachmi Setiyaningsih,Claudio L. Afonso +10 more
TL;DR: The co-evolution of at least three different sub-genotypes reported here and the apparent close relationship of some of those genotypes from ND viruses isolated from wild birds, suggests that identifying wild life reservoirs may help predict new panzootics.
Journal ArticleDOI
Highly Divergent Virulent Isolates of Newcastle Disease Virus from the Dominican Republic Are Members of a New Genotype That May Have Evolved Unnoticed for Over 2 Decades
Sean C. Courtney,Leonardo Susta,Dejelia Gomez,Nichole Hines,Janice C. Pedersen,Corrie C. Brown,Patti J. Miller,Claudio L. Afonso +7 more
TL;DR: The clear phylogenetic relationship between the 2008, 1986, and 1947 ancestral viruses suggests that virulent NDV strains may have evolved in unknown reservoirs in the Caribbean and surrounding regions and underlines the importance of continued and improved epidemiological surveillance strategies to detect NDV in wild-bird species and commercial poultry.
Journal ArticleDOI
Generation by Reverse Genetics of an Effective, Stable, Live-Attenuated Newcastle Disease Virus Vaccine Based on a Currently Circulating, Highly Virulent Indonesian Strain
Sa Xiao,Baibaswata Nayak,Arthur S. Samuel,Anandan Paldurai,Mallikarjuna Kanabagattebasavarajappa,Teguh Y. Prajitno,Eny E. Bharoto,Peter L. Collins,Siba K. Samal +8 more
TL;DR: Results suggest that Ban/AF can provide better protection than commercial vaccines and is a promising vaccine candidate against NDV strains circulating in Indonesia.
Journal ArticleDOI
Characterisation of genotype VII Newcastle disease virus (NDV) isolated from NDV vaccinated chickens, and the efficacy of LaSota and recombinant genotype VII vaccines against challenge with velogenic NDV.
TL;DR: The protection efficacy of the recombinant genotype VII NDV inactivated vaccine was evaluated when added to an existing commercial vaccination program against challenge with velogenic NDV IBS002 and NDV AF2240-I in commercial broilers and indicated that both LaSota and recombinant Genotype VII vaccines offered full protection against challenge.
References
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Rescue of Newcastle disease virus from cloned cDNA: evidence that cleavability of the fusion protein is a major determinant for virulence
TL;DR: It is demonstrated that genetically modified NDV can be recovered from cloned cDNA and confirmed the supposition that cleavage of the F0 protein is a key determinant in virulence of NDV.
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Third genome size category of avian paramyxovirus serotype 1 (Newcastle disease virus) and evolutionary implications
TL;DR: The goal of the study was to establish if there was a relationship between molecular patterns and virus evolution, and the complete genome sequence of two distinct apathogenic Newcastle disease virus (NDV) strains was determined and a third genome size category, containing 15,198 nucleotides, was recognized.
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Newcastle disease: Evolution of genotypes and the related diagnostic challenges
TL;DR: The molecular epidemiology and recent diagnostic problems related to viral evolution of NDV are reviewed and it is explained why a new system, based on objective criteria, is needed to categorize genotypes.
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Role of fusion protein cleavage site in the virulence of Newcastle disease virus.
TL;DR: The results demonstrate that the efficiency of cleavage of the F protein plays an important role if the NDV is delivered directly into the brains of chicks, but there could be other viral factors that probably affect peripheral replication, viremia, or entry into the central nervous system.