Book ChapterDOI
Complex Maze Learning in Rodents
Donald K. Ingram
- pp 451-467
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TLDR
Poon et al. as mentioned in this paper found that the most salient age-related change appears in the ability to use secondary memory systems which represent the unlimited permanent store of newly acquired information.Abstract:
An extensive body of research findings supports the view that normal aging in humans is associated with a defined dysfunction in memory processing. When sensorimotor performance requirements of tasks can be equated across age groups, the most salient age-related change appears in the ability to use secondary memory systems which represent the unlimited permanent store of newly acquired information (Poon, 1985). Age differences in sensory memory, which refers to the brief storage of sensory information; in primary memory, which refers to the temporary, limited capacity repository available for immediate recall; and in tertiary memory, which refers to memory for remote events, appear less robust (Poon, 1985). Much of the age-related impairment in retrieval of information from secondary memory can be attributed to deficient encoding processes, including organizational skills, visual imagination, depth of processing, and attention, as well as problems of equating motivational factors (Kausler, 1982; Poon, 1985). In terms of a storage-deficit hypothesis of age-related memory dysfunction, reviews of the literature have indicated that age differences in forgetting rates are minimal or nonexistent when effort is made to equate the original level of learning (Poon, 1985).read more
Citations
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Journal ArticleDOI
Oxidative stress protection and vulnerability in aging: putative nutritional implications for intervention.
TL;DR: The beneficial effects of the polyphenolics found in fruits and vegetables in neuronal aging and behavior may be similar to those seen with respect to carcinogenesis and cardiovascular disease.
Journal ArticleDOI
Hemodynamic changes during aging associated with cerebral blood flow and impaired cognitive function
Ranjeet S. Ajmani,E.J Metter,R Jaykumar,Donald K. Ingram,E.L Spangler,O.O Abugo,Joseph M. Rifkind +6 more
TL;DR: The results suggest that in aging, oxidative stress as well as amyloids may influence the fluid properties of blood, resulting in a potential decrement in blood flow and oxygen delivery to the brain.
Journal ArticleDOI
AGE-RELATED NEURODEGENERATION AND OXIDATIVE STRESS Putative Nutritional Intervention
James A. Joseph,Natalie Denisova,Derek R. Fisher,Barbara Shukitt-Hale,Paula C. Bickford,Ronald L. Prior,Giohua Cao +6 more
TL;DR: Evidence is presented to show that the abilities to mitigate the OS effects and to repair the damage from OS show decline as a function of age, and attempts to increase antioxidant protection through diets identified as being high in total antioxidant activity might prevent or reverse the deleterious OS effects on neuronal aging.
Journal ArticleDOI
The putative role of free radicals in the loss of neuronal functioning in senescence.
TL;DR: Research is described that indicates that the oxidative neural damage that occurs via kainic acid or ionizing radiation parallel those seen in aging and that the common mechanism that may exist among all of the age-, disease, excitatory amino acid- or radiation-induced deficits in neuronal transmission may involve free-radical-mediated alterations in membrane integrity through lipid peroxidation.
Journal ArticleDOI
New pharmacological strategies for cognitive enhancement using a rat model of age-related memory impairment.
Donald K. Ingram,Edward L. Spangler,Setsu Iijima,Hui Kuo,Elaine L. Bresnahan,Nigel H. Greig,Edythe D. London +6 more
TL;DR: The identification of NO as a simple molecule serving vital physiological functions but representing potential for neurotoxicity presents an important unifying area for neurobiological investigations searching for mechanisms of normal brain aging and of age-related neuropathology, as observed in Alzheimer's disease.
References
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Journal ArticleDOI
The Cholinergic Hypothesis of Geriatric Memory Dysfunction
Raymond T. Bartus,Raymond T. Bartus,Reginald L. Dean,Bernard Beer,Bernard Beer,Arnold S. Lippa,Arnold S. Lippa +6 more
TL;DR: Biochemical, electrophysiological, and pharmacological evidence supporting a role for cholinergic dysfunction in age-related memory disturbances is critically reviewed and an attempt has been made to identify pseudoissues, resolve certain controversies, and clarify misconceptions that have occurred in the literature.
Book
Handbook of the Psychology of Aging
TL;DR: The Handbook of the Psychology of Aging, Seventh Edition, provides a basic reference source on the behavioral processes of aging for researchers, graduate students, and professionals and provides perspectives on the Behavioral Science of Aging for researchers and professionals from other disciplines.
Journal ArticleDOI
Hippocampus, space, and memory
TL;DR: It is proposed that the hippocampus is selectively involved in behaviors that require working memory, irrespective of the type of material (spatial or nonspatial) that is to be processed by that memory.
Book
Neuropsychology of memory
Larry R. Squire,Nelson Butters +1 more
TL;DR: This paper presents a summary of presently available information about the neuropsychology of human memory, emphasizing three ideas: a) the neural substrate of memory continues to change for a long time after initial learning, which is distinct from the changes underlying forgetting and involves the medial temporal region of the brain.