Journal ArticleDOI
Complex regional pain syndrome: A comprehensive and critical review
Andrea T. Borchers,M E Gershwin +1 more
TLDR
A detailed critical overview of not only the history of CRPS, but also the epidemiology, the clinical features, the pathophysiological studies, the proposed criteria, the therapy and an emphasis that future research should apply more rigorous standards to allow a better understanding ofCRPS are provided.About:
This article is published in Autoimmunity Reviews.The article was published on 2014-03-01. It has received 176 citations till now. The article focuses on the topics: Complex regional pain syndrome.read more
Citations
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Journal ArticleDOI
Is Tactile Acuity Altered in People With Chronic Pain? A Systematic Review and Meta-analysis
Mark J. Catley,Neil E O'Connell,Carolyn Berryman,Figen Ayhan,G. Lorimer Moseley,G. Lorimer Moseley +5 more
TL;DR: The results suggest that tactile acuity is diminished in arthritis, complex regional pain syndrome, and chronic low back pain but not in burning mouth syndrome and that tactile Acuity training may benefit those with chronic pain disorders, and suggests that clinical trials may be warranted.
Journal ArticleDOI
Neurogenic neuroinflammation in fibromyalgia and complex regional pain syndrome
TL;DR: The differing degrees to which neurogenic neuroinflammation might contribute to the multifactorial pathogenesis of both fibromyalgia and CRPS are highlighted, and the evidence suggesting that this mechanism is an important link between the two disorders, and could offer novel therapeutic targets is discussed.
Journal ArticleDOI
Pathological mechanisms and therapeutic outlooks for arthrofibrosis.
Kayley M. Usher,Sipin Zhu,Georgios Mavropalias,John A. Carrino,Jinmin Zhao,Jiake Xu,Jiake Xu +6 more
TL;DR: The researchers propose the existence of two subtypes of arthrofibrosis—one involving active scar formation, and one in which inflammatory processes have resolved—and they suggest each should be treated differently.
Referred sensations in patients with complex regional pain syndrome type 1 (CRPS) [Abstract]
Abstract: OBJECTIVES
This study sought to explore and characterize referred sensations (RS) in patients with complex regional pain syndrome (CRPS) type 1 and test the hypothesis that pain in CRPS is associated with central sensory changes.
METHODS
Subjects underwent standardized neurological examination involving light touch, pinprick and vibration sense with eyes closed and then with eyes open. The subjects described the location and sensation emanating from the stimulated site and whether they experienced any sensations (similar or different) elsewhere.
RESULTS
Five of 16 subjects recruited demonstrated RS. These were experienced in real time, were modality specific (touch and pinprick) and were located on the body part immediately adjacent, on Penfield's cortical homunculus, to the stimulated site. The RS were diminished or absent when the subject visualized the stimulated area. They disappeared when stimulation ceased and on clinical improvement.
CONCLUSIONS
This is the first report of RS in CRPS and provides further evidence of central reorganization in what was previously thought to be a peripheral disorder.
References
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Book
Classification of Chronic Pain: Descriptions of Chronic Pain Syndromes and Definitions of Pain Terms
Journal ArticleDOI
Central sensitization: implications for the diagnosis and treatment of pain.
TL;DR: Diagnostic criteria to establish the presence of central sensitization in patients will greatly assist the phenotyping of patients for choosing treatments that produce analgesia by normalizing hyperexcitable central neural activity.
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Central Sensitization: A Generator of Pain Hypersensitivity by Central Neural Plasticity
TL;DR: The major triggers that initiate and maintain central sensitization in healthy individuals in response to nociceptor input and in patients with inflammatory and neuropathic pain are reviewed, emphasizing the fundamental contribution and multiple mechanisms of synaptic plasticity caused by changes in the density, nature, and properties of ionotropic and metabotropic glutamate receptors.
Journal ArticleDOI
Human brain mechanisms of pain perception and regulation in health and disease.
TL;DR: A systematic review of the literature regarding how activity in diverse brain regions creates and modulates the experience of acute and chronic pain states, emphasizing the contribution of various imaging techniques to emerging concepts is presented in this paper.