Journal ArticleDOI
Confirmation of initial antiphospholipid antibody positivity depends on the antiphospholipid antibody profile.
Vittorio Pengo,Amelia Ruffatti,T. Del Ross,Marta Tonello,S Cuffaro,Ariela Hoxha,Alessandra Banzato,E. Bison,Gentian Denas,A. Bracco,S. Padayattil Jose +10 more
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TLDR
The revised classification criteria for the antiphospholipid syndrome state that antiph phosphate antibodies should be detected on two or more occasions at least 12 weeks apart.About:
This article is published in Journal of Thrombosis and Haemostasis.The article was published on 2013-08-01. It has received 85 citations till now. The article focuses on the topics: Antiphospholipid antibody positivity & Lupus anticoagulant.read more
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Journal ArticleDOI
Laboratory criteria for antiphospholipid syndrome: communication from the SSC of the ISTH.
TL;DR: Coagulation Laboratory, Department of Laboratory Medicine, Ghent University Hospital, Gent, Belgium; †Departments of Medicine and Pathology, Duke University Medical Center, Durham, NC, USA; and ¶Synapse BV, Maastricht, the Netherlands.
Journal ArticleDOI
Guidance from the Scientific and Standardization Committee for lupus anticoagulant/antiphospholipid antibodies of the International Society on Thrombosis and Haemostasis : update of the guidelines for lupus anticoagulant detection and interpretation
Katrien Devreese,Katrien Devreese,Philip G. de Groot,Bas de Laat,Doruk Erkan,Emmanuel J. Favaloro,Ian J. Mackie,Marta Martinuzzo,Thomas L. Ortel,Vittorio Pengo,Jacob H. Rand,Armando Tripodi,Denis Wahl,Hannah Cohen,Hannah Cohen +14 more
TL;DR: This guidance focuses on methodological aspects of lupus anticoagulant (LA) testing, as well as interpretation of results for clinicians, with main changes in how to test for LA compared with the International Society on Thrombosis and Haemostasis Scientific and Standardization Committee 2009 guidelines.
Journal ArticleDOI
Antiphospholipid antibodies in patients with COVID-19: A relevant observation?
TL;DR: High incidence of thrombosis in COVID‐19 patients indicates a hypercoagulable state, hence, exploring the involvement of antiphospholipid antibodies (aPL) in these patients is of interest.
Journal ArticleDOI
Antiphospholipid syndrome: antibodies to Domain 1 of β2-glycoprotein 1 correctly classify patients at risk.
Vittorio Pengo,A. Ruffatti,Marta Tonello,S Cuffaro,Alessandra Banzato,E. Bison,Gentian Denas,S. Padayattil Jose +7 more
TL;DR: Determination of lupus anticoagulant (LA), anticardiolipin (aCL) and β2‐Glycoprotein 1 (aβ2GP1) antibodies is mandatory to classify patients with antiphospholipid syndrome (APS) into risk categories.
Journal ArticleDOI
Efficacy and safety of rivaroxaban vs warfarin in high-risk patients with antiphospholipid syndrome: Rationale and design of the Trial on Rivaroxaban in AntiPhospholipid Syndrome (TRAPS) trial:
Vittorio Pengo,Alessandra Banzato,E. Bison,Giacomo Zoppellaro,S. Padayattil Jose,Gentian Denas +5 more
TL;DR: This is a multicentre, randomized, open-label, study that will evaluate if Rivaroxaban is non-inferior to warfarin for the prevention of thromboembolic events, major bleeding and death in high risk (triple positive) patients with antiphospholipid syndrome.
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International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS).
Spiros Miyakis,Michael D. Lockshin,Tatsuya Atsumi,D W Branch,Robin L. Brey,Ricard Cervera,R. H. W. M. Derksen,P. G. De Groot,Takao Koike,Pier Luigi Meroni,Guido Reber,Yehuda Shoenfeld,Angela Tincani,Panayiotis G. Vlachoyiannopoulos,Steven A. Krilis +14 more
TL;DR: This document appraise the existing evidence on clinical and laboratory features of APS addressed during the forum and proposes amendments to the Sapporo criteria, including definitions on features ofAPS that were not included in the updated criteria.
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Criteria for the diagnosis of lupus anticoagulants: an update. On behalf of the Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibody of the Scientific and Standardisation Committee of the ISTH.
Journal ArticleDOI
Update of the guidelines for lupus anticoagulant detection
Vittorio Pengo,Armando Tripodi,Guido Reber,Jacob H. Rand,Thomas L. Ortel,Monica Galli,de Peter Groot +6 more
TL;DR: Modalities for blood collection and processing are fully delineated and the choice of tests is limited to dRVVT and a sensitive aPTT and the interpretation of the results in general and in particular situations is reported.
Journal ArticleDOI
A Comparison of Two Intensities of Warfarin for the Prevention of Recurrent Thrombosis in Patients with the Antiphospholipid Antibody Syndrome
Mark Crowther,Jeffrey S. Ginsberg,Jim A. Julian,Judah A. Denburg,Jack Hirsh,James D. Douketis,Carl A. Laskin,Paul R. Fortin,David C. Anderson,Clive Kearon,Ann E. Clarke,William Geerts,Melissa A. Forgie,David Green,Lorrie Costantini,Wendy Yacura,Sarah E. Wilson,Michael Gent,Michael J. Kovacs +18 more
TL;DR: The low rate of recurrent thrombosis among patients in whom the target INR was 2.0 to 3.0 suggests that moderate-intensity warfarin is appropriate for patients with the antiphospholipid antibody syndrome.
Journal ArticleDOI
Clinical course of high-risk patients diagnosed with antiphospholipid syndrome
Vittorio Pengo,Amelia Ruffatti,Cristina Legnani,Paolo Gresele,Doris Barcellona,Nicoletta Erba,Sophie Testa,Francesco Marongiu,E. Bison,Gentian Denas,Alessandra Banzato,S. Padayattil Jose,Sabino Iliceto +12 more
TL;DR: The antiphospholipid triangle is studied as a model for the stationary phase of the response of the immune system to various types of drugs.