Journal ArticleDOI
Contamination of 2-deoxy-2-[18F]fluoro-d-mannose in the 2-deoxy-2-[18F]fluoro-d-glucose preparations synthesized from [18F]acetyl hypofluorite and [18F]F2
Reads0
Chats0
TLDR
In this paper, the presence of 2-deoxy-2-18-tri-O -acetyl-d-glucal (TAG) with [ 18 F]acetyl hypofluorite (FDM) was quantified by radio HPLC analysis of reacetylated [18 F]FDG.About:
This article is published in International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes.The article was published on 1987-01-01. It has received 12 citations till now. The article focuses on the topics: Glucal.read more
Citations
More filters
Book ChapterDOI
Chemistry and Developments of Fluorinated Carbohydrates
TL;DR: This chapter presents a review about the chemistry and developments of fluorinated carbohydrates, a review of natural nucleoside analogs having effective antiviral and antitumor activities with low cytotoxicity for the host cells.
Journal ArticleDOI
Procedures, pitfalls and solutions in the production of [18F]2-deoxy-2-fluoro-d-glucose: A paradigm in the routine synthesis of fluorine-18 radiopharmaceuticals
TL;DR: The procedures for making [ 18 F]2-deoxy-2-fluoro-dglucose are reviewed with emphasis on the requirements for routine production in this paper, and the controversy involved in the use of the compound are covered briefly.
Journal ArticleDOI
Carbohydrate‐Based Molecules for Molecular Imaging in Nuclear Medicine
TL;DR: This review covers published literature describing the synthesis of labeled carbohydrates for use in molecular imaging, with a particular focus on the use of nuclear techniques (PET, SPECT), andRecent advances in the radiosynthesis of [18F]FDG are considered.
Journal ArticleDOI
The stability of 2-[18F]fluoro-deoxy-d-glucose towards epimerisation under alkaline conditions
Geerd-J. Meyer,K.-H. Matzke,K Hamacher,F Füchtner,Joerg Steinbach,G Notohamiprodjo,S Zijlstra +6 more
TL;DR: In this paper, a multi-centre study has been performed to check the safety of this method for routine production of 2-fluoro-deoxy-d-glucose (18 FDG) in view of the quality standards set by the European Pharmacopoeia.
Journal ArticleDOI
Tumor diagnosis by PET: potential of seven tracers examined in five experimental tumors including an artificial metastasis model.
Kiichi Ishiwata,Toshihiro Takahashi,Ren Iwata,M. Tomura,Masao Tada,Jun Itoh,Motonobu Kameyama,Tatsuo Ido +7 more
TL;DR: The tumor-to-tissue uptake ratios indicated that the nucleosides, [11C]Met and 6-[18F]FFuc were better tracers in the brain region and the combined use of these radiotracers can possibly allow the assessment of tumor metabolism, and this indicates the viability of tumors.
References
More filters
Journal ArticleDOI
A Fluorinated Glucose Analog, 2-fluoro-2-deoxy-D-glucose (F-18): Nontoxic Tracer for Rapid Tumor Detection
Peter M. Som,Harold L. Atkins,D Bandoypadhyay,Joanna S. Fowler,Robert R. MacGregor,K. Matsui,Z.H. Oster,D.F. Sacker,Chyng-Yann Shiue,H Turner,C.N. Wan,Alfred P. Wolf,S V Zabinski +12 more
TL;DR: Rapid uptake of F-18 FDG was observed in a variety of transplanted and spontaneous tumors in animals, and a scintiscan of a seminoma in a dog showed very high uptake in the viable part and lack of uptake inThe necrotic mass.
Journal ArticleDOI
Identification and differentiation of resting myocardial ischemia and infarction in man with positron computed tomography, 18F-labeled fluorodeoxyglucose and N-13 ammonia.
Robert C. Marshall,Jan H. Tillisch,Michael E. Phelps,Sung-Cheng Huang,Richard E. Carson,Eberhard Henze,Heinrich R. Schelbert +6 more
TL;DR: The changes in regional FDG and N-13 ammonia concentrations detected with PCT in patients who had had a recent myocardial infarction are consistent with regional exogenous glucose utilization and perfusion in moderately ischemic and irreversibly infarcted myocardium.
Journal ArticleDOI
Labeled 2-deoxy-D-glucose analogs. 18F-labeled 2-deoxy-2-fluoro-D-glucose, 2-deoxy-2-fluoro-D-mannose and 14C-2-deoxy-2-fluoro-D-glucose
TL;DR: 14C- 2-deoxy-2-fluoro-D-glucose has been synthesized from 14C-3,4,6-tri-0-acetyl-D -glucal by fluorination with F2 and CF3OF to study of local cerebral glucose metabolism.
Journal ArticleDOI
Study of Cerebral Function with Positron Computed Tomography
TL;DR: Abbreviations: ACD, Annihilation coincidence detection; BGO, bismuth germanate; CBF, cerebral blood flow; CBV, cerebralBlood volume; CMG, 3-(11C)-methyl-D-glucose; CMRGlc, cerebral metabolic rate for glucose'; CMR02, cerebral metabolism rate for oxygen; CsF, cesium fluoride; CT, computed tomography
Journal Article
Increased accumulation of 2-deoxy-2-[18F]Fluoro-D-glucose in liver metastases from colon carcinoma.
Yoshiharu Yonekura,Richard S. Benua,A.B. Brill,Peter M. Som,Samuel D.J. Yeh,Nancy E. Kemeny,Joanna S. Fowler,Robert R. MacGregor,Stamm R,David R. Christman,Alfred P. Wolf +10 more
TL;DR: Preliminary results suggest that F-18-FDG may be useful as a positive imaging agent for the detection and characterization of liver tumors in patients with liver metastases from colon carcinoma.