CPAP for Prevention of Cardiovascular Events in Obstructive Sleep Apnea
Ronald McEvoy,Nick A. Antic,Emma Heeley,Y. Luo,Qiong Ou,Xilong Zhang,Olga Mediano,Rui Chen,Luciano F. Drager,Zhihong Liu,Guofang Chen,Bin Du,Nigel McArdle,Sutapa Mukherjee,Manjari Tripathi,Laurent Billot,Qiang Li,Geraldo Lorenzi-Filho,Ferran Barbé,Susan Redline,Jiguang Wang,Hisatomi Arima,Bruce Neal,David P. White,Ronald R. Grunstein,Nanshan Zhong,Craig S. Anderson +26 more
TLDR
Therapy with CPAP plus usual care, as compared with usual care alone, did not prevent cardiovascular events in patients with moderate-to-severe obstructive sleep apnea and established cardiovascular disease.Abstract:
BackgroundObstructive sleep apnea is associated with an increased risk of cardiovascular events; whether treatment with continuous positive airway pressure (CPAP) prevents major cardiovascular events is uncertain. MethodsAfter a 1-week run-in period during which the participants used sham CPAP, we randomly assigned 2717 eligible adults between 45 and 75 years of age who had moderate-to-severe obstructive sleep apnea and coronary or cerebrovascular disease to receive CPAP treatment plus usual care (CPAP group) or usual care alone (usual-care group). The primary composite end point was death from cardiovascular causes, myocardial infarction, stroke, or hospitalization for unstable angina, heart failure, or transient ischemic attack. Secondary end points included other cardiovascular outcomes, health-related quality of life, snoring symptoms, daytime sleepiness, and mood. ResultsMost of the participants were men who had moderate-to-severe obstructive sleep apnea and minimal sleepiness. In the CPAP group, the...read more
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