Journal ArticleDOI
Cu(II) and Mn(II) complexes containing macroacyclic ligand: synthesis, DNA binding, and cleavage studies.
TLDR
The enhancement in the relative viscosity of DNA on binding to the ligand supports the proposed DNA binding modes.Abstract:
The two new metal complexes of Cu(II) and Mn(II) containing macroacyclic ligand of the type [Cu(hpn)](PF6)2 (1) and [Mn(hpn)](PF6)2 (2) [where hpn = [1-{[2-{[2-hydroxynaphthalen-1-yl)methylidine]am...read more
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Synthesis, spectral characterization and biological studies of Cu (II), Co (II) and Ni (II) complexes of azo dye ligand containing 4‒amino antipyrine moiety
TL;DR: A series of biologically active azo dye ligands, HL1 and HL2 have been synthesized by conventional diazo-coupling reaction at 0-5 °C.
Journal ArticleDOI
Synthesis, XRD, thermal, spectroscopic studies and biological evaluation of Co(II), Ni(II) Cu(II) metal complexes derived from 2-benzimidazole
Journal ArticleDOI
Metal complexes of quinolin-8-yl [(5-methoxy-1H-benzimidazol-2-yl)sulfanyl]acetate: Spectral, XRD, thermal, cytotoxic, molecular docking and biological evaluation
Journal ArticleDOI
Novel bioactive azo-azomethine based Cu (II), Co (II) and Ni(II) complexes, structural determination and biological activity
TL;DR: In this paper, a novel bioactive azo-azomithine tridentate ligand N'-(E)-{2-hydroxy-3-methoxy-5-[(E)phenyldiazenyl]phenyl}methylidene]pyridine-3 carbohydrazide (HL) and its Cu(II), Co(II) and Ni(II)) complexes were synthesized and their structure determined by elemental analysis, spectroscopic studies (FTIR, 1H NMR, 13C NMR), LC-MS, UV
Journal ArticleDOI
Synthesis, characterization and tumor inhibitory activity of a novel Pd(II) complex derived from methanethiol-bridged (2-((1H-benzo[d]imidazol-2-yl)methylthio)-1H-benzo[d]imidazol-6-yl)(phenyl)methanone
N. Sunil Kumar,G. Krishnamurthy,Yadav D. Bodke,Vikas H. Malojirao,T. R. Ravikumar Naik,Shivananda Kandagalla,B.T. Prabhakar +6 more
TL;DR: In this article, a therapeutic active Pd(II) complex with the new (2-((1H-benzo[d]imidazol-2-yl)methylthio)-1Hbenzo [d]dimidazole ligand in good yield was designed and its structure of the ligand and its Pd-II complex was characterized via IR, UV-visible, 1H NMR, 13C-NMR, mass spectroscopy, TGA and powder XRD techniques.
References
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Journal ArticleDOI
A Further Examination of the Molecular Weight and Size of Desoxypentose Nucleic Acid
Journal ArticleDOI
Polycyclic aromatic hydrocarbons physically intercalate into duplex regions of denatured DNA
TL;DR: It appears that physical binding of polycyclic aromatic hydrocarbons consists of intercalation into these sites, and increasing salt concentration increases the duplex content of denatured DNA.
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Tris(phenanthroline)ruthenium(II) enantiomer interactions with DNA: Mode and specificity of binding
TL;DR: The results of these studies indicated that both isomers bind to DNA by a single mode, but the two isomers differ, however, in their effect on the hydrodynamic properties of DNA as measured by viscosity and, therefore, probably differ in their individual binding modes.
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Tris(phenanthroline)ruthenium(II): stereoselectivity in binding to DNA
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Metals in Medicine
Zijian Guo,Peter J. Sadler +1 more
TL;DR: In the fight against cancer cisplatin, one of the world's best selling anticancer drugs, is being joined by other platinum, titanium, and ruthenium complexes, and metal-targeted organic agents show exciting clinical potential.