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A Further Examination of the Molecular Weight and Size of Desoxypentose Nucleic Acid
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This article is published in Journal of the American Chemical Society.The article was published on 1954-06-01. It has received 2071 citations till now. The article focuses on the topics: Nucleic acid.read more
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Studies of the binding of actinomycin and related compounds to DNA
Werner Müller,Donald M. Crothers +1 more
TL;DR: The physical property which distinguishes actinomycin from the simpler analogs (which lack biological activity) is a very slow dissociation reaction, several orders of magnitude slower than for the non-active analogs.
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The native, denatured and renatured states of deoxyribonucleic acid
Joseph Eigner,Paul Doty +1 more
TL;DR: New and published data are analyzed to show that light-scattering determinations of molecular weight are uniformly reliable only below 3 million, and that the value of the Scheraga-Mandelkern constant β evidently remains very close to 2·4 × 10 6 throughout the molecular weight range of 200,000 to 200 million.
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A single-stranded deoxyribonucleic acid from bacteriophage φX174
TL;DR: It is concluded that the DNA of bacteriophage φX174 is single-stranded, and light scattering studies indicate that this DNA is highly flexible and that its configuration is strongly dependent upon the ionic strength of the solution.
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The isolation and properties of deoxyribonucleoprotein particles containing single nucleic acid molecules
Geoffrey Zubay,Paul Doty +1 more
TL;DR: It is shown that a large fraction of the histone can be accommodated in sections having the α-helical configuration in the large groove of the double-stranded deoxyribonucleic acid helix and that such a model is consistent with the observations made thus far.
Journal ArticleDOI
DNA binding and cleavage properties of certain tetrammine ruthenium(II) complexes of modified 1,10-phenanthrolines--effect of hydrogen-bonding on DNA-binding affinity.
TL;DR: The results from absorption spectral titration and circular dichroism (CD), thermal denaturation and viscosity experiments indicate that the qdppZ and hqdppz complexes bind more avidly than the ip, pip and hpip complexes, and the ammonia co-ligands of the complexes are possibly involved in hydrogen bonding with the intrastrand nucleobases to favour intercalation of the extended aromatic ligands.