Patent
Cyclic dinucleotides for treating conditions associated with sting activity such as cancer
TLDR
In this article, dinucleotide compounds that modulate Stimulator of Interferon Genes (STING) activity for use for example in the treatment of cancer were discussed.Abstract:
This disclosure features dinucleotide compounds that modulate Stimulator of Interferon Genes (STING) activity, for use for example in the treatment of cancer. This disclosure also features compositions as well as other methods of using and making the same. A and B are each independently selected from the group consisting of Formulae (i), (ii), (iii), and (iv):read more
Citations
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Patent
Cyclic di-nucleotide compounds as sting agonists
Michael D. Altman,Brian M. Andresen,Wonsuk Chang,Matthew Lloyd Childers,Jared N. Cumming,Andrew M. Haidle,Timothy J. Henderson,James P. Jewell,Rui Liang,Jongwon Lim,Hong Liu,Min Lu,Alan B. Northrup,Ryan D. Otte,Tony Siu,Benjamin Wesley Trotter,Quang T. Truong,Shawn P. Walsh,Kake Zhao +18 more
TL;DR: In this article, a class of polycyclic compounds of general formula (II), of general form (II'), or of general condition (II) was defined, which may be useful as inductors of type I interferon production, specifically as STING active agents.
Patent
Cyclic di-nucleotide compounds and methods of use
TL;DR: In this article, cyclic-di-nucleotide cGAMP analogs, methods of synthesizing the compounds, pharmaceutical compositions comprising the compounds thereof, and use of compounds and compositions in medical therapy are discussed.
Patent
BENZO[b]THIOPHENE COMPOUNDS AS STING AGONISTS
Michael D. Altman,Brandon Cash,Wonsuk Chang,Jared N. Cumming,Andrew M. Haidle,Timothy J. Henderson,James P. Jewell,Matthew A. Larsen,Rui Liang,Jongwon Lim,Min Lu,Ryan D. Otte,Tony Siu,Benjamin Wesley Trotter,Sriram Tyagarajan +14 more
TL;DR: In this article, the authors defined a set of compounds that may be useful as inductors of type I interferon production, specifically as STING active agents, and provided processes for the synthesis and use of compounds of the disclosure.
Journal ArticleDOI
Small molecule immuno-oncology therapeutic agents.
TL;DR: This perspective provides an overview of some of the many small molecule approaches being explored in cancer treatment, which encompasses small molecule modulators of validated targets such as programed cell death 1 (PD-1) as well as novel approaches still to be proven clinically.
Patent
Compounds, compositions, and methods for the treatment of disease
Radhakrishnan P. Iyer,Seetharamaiyer Padmanabhan,Dillon Cleary,Geeta Meher,Rayomand Gimi,Anjaneyulu Sheri,Shenghua Zhou,Sreerupa Challa +7 more
TL;DR: In this article, the authors describe compounds and compositions for the induction of expression of a pattern recognition receptor (e.g., STING) and methods of use thereof, and propose a method of using STING for pattern recognition.
References
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Book
Protective groups in organic synthesis
TL;DR: In this article, the most useful groups for the hydroxyl, amino, carboxyl, carbonyl, and sulfhydryl groups are discussed and the chemistry of the classes of these groups, as well as that of individual groups within the class using structures, equations and references.
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Remington : The Science and Practice of Pharmacy
TL;DR: Remington: The Science and Practice of Pharmacy now includes six months free online access to Facts and Comparisons's DrugfactsPlus, the leading source of drug information and pharmacist tools on the Internet.
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Handbook of Pharmaceutical Excipients
TL;DR: The Handbook of Pharmaceutical Excipients is internationally recognised as the authoritative source of information on pharmaceutical excipients giving a comprehensive guide to uses, properties and safety.
Journal ArticleDOI
Immune Checkpoint Blockade in Cancer Therapy
TL;DR: Concluding remarks are made that principles learned during the development of CTLA-4 and PD-1/PD-L1 approaches will likely be used as new immunologic checkpoint blocking antibodies begin clinical investigation, and whether they enhance the efficacy of either approach alone is investigated.