Patent
Cyclic di-nucleotide compounds and methods of use
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In this article, cyclic-di-nucleotide cGAMP analogs, methods of synthesizing the compounds, pharmaceutical compositions comprising the compounds thereof, and use of compounds and compositions in medical therapy are discussed.Abstract:
Disclosed are cyclic-di-nucleotide cGAMP analogs, methods of synthesizing the compounds, pharmaceutical compositions comprising the compounds thereof, and use of compounds and compositions in medical therapy.read more
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Cyclic di-nucleotide compounds as sting agonists
Michael D. Altman,Brian M. Andresen,Wonsuk Chang,Matthew Lloyd Childers,Jared N. Cumming,Andrew M. Haidle,Timothy J. Henderson,James P. Jewell,Rui Liang,Jongwon Lim,Hong Liu,Min Lu,Alan B. Northrup,Ryan D. Otte,Tony Siu,Benjamin Wesley Trotter,Quang T. Truong,Shawn P. Walsh,Kake Zhao +18 more
TL;DR: In this article, a class of polycyclic compounds of general formula (II), of general form (II'), or of general condition (II) was defined, which may be useful as inductors of type I interferon production, specifically as STING active agents.
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Cyclic purine dinucleotides as sting (stimulator of inteferon genes) agonists
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TL;DR: In this paper, a compound having a STING (stimulator of interferon genes) agonistic activity, which may be expected to be useful as an agent for the prophylaxis or treatment of STING-related diseases, such as cancer, is presented.
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Cyclic dinucleotides for treating conditions associated with sting activity such as cancer
TL;DR: In this article, dinucleotide compounds that modulate Stimulator of Interferon Genes (STING) activity for use for example in the treatment of cancer were discussed.
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BENZO[b]THIOPHENE COMPOUNDS AS STING AGONISTS
Michael D. Altman,Brandon Cash,Wonsuk Chang,Jared N. Cumming,Andrew M. Haidle,Timothy J. Henderson,James P. Jewell,Matthew A. Larsen,Rui Liang,Jongwon Lim,Min Lu,Ryan D. Otte,Tony Siu,Benjamin Wesley Trotter,Sriram Tyagarajan +14 more
TL;DR: In this article, the authors defined a set of compounds that may be useful as inductors of type I interferon production, specifically as STING active agents, and provided processes for the synthesis and use of compounds of the disclosure.
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Cyclic dinucleotides as sting agonists
Gilles Bignan,Peter J. Connolly,James P. Edwards,Stuart L. Emanuel,Sylvie Laquerre,Lu Tianbao,Mark Richter,Leonid Beigelman,Santhosh Kumar Thatikonda,Guangyi Wang,Minghong Zhong +10 more
TL;DR: In this article, compounds, compositions, and methods for treating viral infections, diseases, syndromes, or disorders that are affected by the modulation of STING are discussed, represented by Formula (I).
References
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Protective groups in organic synthesis
TL;DR: In this article, the most useful groups for the hydroxyl, amino, carboxyl, carbonyl, and sulfhydryl groups are discussed and the chemistry of the classes of these groups, as well as that of individual groups within the class using structures, equations and references.
Journal ArticleDOI
Cyclic GMP-AMP Synthase is a Cytosolic DNA Sensor that Activates the Type-I Interferon Pathway
TL;DR: Results indicate that cGAS is a cytosolic DNA sensor that induces interferons by producing the second messenger cGAMP, which belongs to the nucleotidyltransferase family.
Journal ArticleDOI
A diverse range of gene products are effectors of the type I interferon antiviral response
John W. Schoggins,Sam J. Wilson,Maryline Panis,Mary Murphy,Christopher T. Jones,Paul D. Bieniasz,Charles M. Rice +6 more
TL;DR: It is shown that different viruses are targeted by unique sets of ISGs, and that each viral species is susceptible to multiple antiviral genes, which together encompass a range of inhibitory activities.
Journal ArticleDOI
Cyclic-GMP-AMP Is An Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA
TL;DR: Cytosolic DNA induces type I interferons and other cytokines that are important for antimicrobial defense but can also result in autoimmunity, and cGAMP functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolicDNA.
Journal ArticleDOI
STING is a direct innate immune sensor of cyclic di-GMP
Dara Burdette,Kathryn M. Monroe,Katia Sotelo-Troha,Jeffrey S. Iwig,Barbara Eckert,Mamoru Hyodo,Yoshihiro Hayakawa,Russell E. Vance +7 more
TL;DR: It is demonstrated that STING binds directly to radiolabelled cyclic diguanylate monophosphate (c-di-GMP), and it is shown that unlabelledcyclic dinucleotides, but not other nucleotides or nucleic acids, compete with c-di -GMP for binding to STING.