Journal ArticleDOI
Demineralized bone matrix paste formulated with biomimetic PLGA microcarriers for the vancomycin hydrochloride controlled delivery: Release profile, citotoxicity and efficacy against S. aureus.
Marco Govoni,Erwin Pavel Lamparelli,Maria Camilla Ciardulli,Antonietta Santoro,Antonio Oliviero,Ida Palazzo,Ernesto Reverchon,Leonardo Vivarelli,Alessandra Maso,Elisa Storni,Maria Elena Donati,Gianluca Ruspaggiari,Nicola Maffulli,Milena Fini,Giovanna Della Porta,Dante Dallari +15 more
TLDR
This approach points toward the potential of the DBM-carrier-antibiotic system in hampering the bacterial growth with accurately controlled antibiotic release and opens perspectives on functional bone paste with PLGA carriers for the controlled release of bioactive molecules.About:
This article is published in International Journal of Pharmaceutics.The article was published on 2020-05-30. It has received 15 citations till now. The article focuses on the topics: Controlled release & Demineralized bone matrix.read more
Citations
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Journal ArticleDOI
Tendon and Cytokine Marker Expression by Human Bone Marrow Mesenchymal Stem Cells in a Hyaluronate/Poly-Lactic-Co-Glycolic Acid (PLGA)/Fibrin Three-Dimensional (3D) Scaffold.
Maria Camilla Ciardulli,Luigi Marino,Joseph Lovecchio,Emanuele Giordano,Nicholas R. Forsyth,Carmine Selleri,Nicola Maffulli,Nicola Maffulli,Nicola Maffulli,Giovanna Della Porta +9 more
TL;DR: Mechanical signaling, conveyed byHY-FIB to hBM-MSCs, promoted tenogenic gene markers expression and a pro-repair cytokine balance, providing strong evidence in support of the HY-F IB system and its interaction with cells and its potential for use as a predictive in vitro model.
Calcium Phosphate Bone Cements for Local Vancomycin Delivery
TL;DR: A new approach was found in order to increase the drug bioavailability of calcium phosphate bone cements with modification of CPC with novel PLA/vancomycin microcapsules loaded and coated with nanosized hydroxyapatite, which resulted in 85.3±3.1% of vancomYcin release within 43days.
Journal ArticleDOI
Progress and Prospects of Polymer-Based Drug Delivery Systems for Bone Tissue Regeneration.
Vyacheslav Ogay,Ellina A. Mun,Gulshakhar Kudaibergen,Murat Baidarbekov,Kuat Kassymbek,Zharylkasyn Zharkinbekov,Arman Saparov +6 more
TL;DR: The most recent advances in the field of polymer-based drug delivery systems for the promotion of bone tissue regeneration and the physical-chemical modifications of polymers for controlled and sustained release of one or more drugs are discussed.
Journal ArticleDOI
Chondrogenic Commitment of Human Bone Marrow Mesenchymal Stem Cells in a Perfused Collagen Hydrogel Functionalized with hTGF-β1-Releasing PLGA Microcarrier.
Erwin Pavel Lamparelli,Joseph Lovecchio,Maria Camilla Ciardulli,Valentina Giudice,Tina P. Dale,Carmine Selleri,Nicholas R. Forsyth,Emanuele Giordano,Nicola Maffulli,Giovanna Della Porta +9 more
TL;DR: In this paper, a 3D biomimetic environment with the capacity to direct stem cell commitment towards a chondrogenic phenotype was used for cartilage repair and regeneration, where a collagen matrix was functionalized with the addition of poly-lactic-co-glycolic acid microcarriers (PLGA-MCs) carrying a human TFG-β1 payload.
Journal ArticleDOI
Supercritical emulsion extraction fabricated PLA/PLGA micro/nano carriers for growth factor delivery: Release profiles and cytotoxicity
Ida Palazzo,Erwin Pavel Lamparelli,Maria Camilla Ciardulli,Pasqualina Scala,Ernesto Reverchon,Nicholas R. Forsyth,Nicola Maffulli,Nicola Maffulli,Antonietta Santoro,Giovanna Della Porta +9 more
TL;DR: Microencapsulation of two human growth factors exhibited extremely low cytotoxicity when evaluated in Chinese Hamster Ovary cells, and low reactivity on human peripheral blood mononuclear cells (hPBMCs), suggesting their safety and potential use in tissue engineering protocols.
References
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Development of the EUCAST disk diffusion antimicrobial susceptibility testing method and its implementation in routine microbiology laboratories
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The Rationale for Revising the Clinical and Laboratory Standards Institute Vancomycin Minimal Inhibitory Concentration Interpretive Criteria for Staphylococcus aureus
TL;DR: The Clinical and Laboratory Standards Institute (formerly, the NCCLS) established the susceptibility and resistance breakpoints for minimal inhibitory concentration (MIC) and disk diffusion testing of vancomycin against isolates of Staphylococcus aureus > 20 years ago.