Journal ArticleDOI
Demonstration of the chemotactic properties of collagen.
C. Chang,J. C. Houck +1 more
TLDR
An in vivo method for measuring chemotaxis has been described using Millipore filters and demonstrated that soluble collagen, but not gelatin, was quite chemotactic.Abstract:
SummaryAn in vivo method for measuring chemotaxis has been described using Millipore filters. This method demonstrated that soluble collagen, but not gelatin, was quite chemotactic. Further, the products of collagenolysis produced by cutaneous collagenase, but not by bacterial collagenase, were extraordinarily chemotactic for polymorphonuclear leukocytes within 4 hr after testing at a concentration of about 0.1 μg.read more
Citations
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Journal ArticleDOI
The Inflammatory Response to Cell Death
Kenneth L. Rock,Hajime Kono +1 more
TL;DR: What is presently known about the sterile inflammatory response and its underlying mechanisms is reviewed.
Journal ArticleDOI
Eccentric exercise-induced injury to rat skeletal muscle
TL;DR: The data generally indicated that eccentric exercise causes greater injury to the muscles, and questions remain.
Journal ArticleDOI
Tetracyclines inhibit connective tissue breakdown: new therapeutic implications for an old family of drugs.
TL;DR: Evidence is presented that this property of tetracycline may be therapeutically useful in retarding pathologic connective tissue breakdown, including bone resorption, and in the treatment of periodontal and several medical diseases.
Journal ArticleDOI
A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation.
Nathaniel M. Weathington,Anneke H. van Houwelingen,Brett D. Noerager,Patricia L. Jackson,Aletta D. Kraneveld,F. Shawn Galin,Gert Folkerts,Frans P. Nijkamp,J. Edwin Blalock +8 more
TL;DR: PGP's activity links degradation of ECM with neutrophil recruitment in airway inflammation, and PGP may be a biomarker and therapeutic target for neutrophilic inflammatory diseases.
Journal ArticleDOI
Collagen-and collagen peptide-induced chemotaxis of human blood monocytes.
TL;DR: The findings suggest the possibility that such collagen-derived degradation products might directly serve as chemotactic stimuli for human peripheral blood monocytes in vivo.
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