Journal ArticleDOI
Deoxyribonucleic Acid Antibody: A Method to Detect Its Primary Interaction with Deoxyribonucleic Acid
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TLDR
This sensitive and specific technique, which measures the primary interaction between DNA and antibody to DNA, is based on the observation that free DNA is soluble in 50-percent saturated ammonium sulfate whereas antibody-bound DNA is insoluble.Abstract:
Antibody to DNA in human serums can be detected by the ammonium sulfate method. This sensitive and specific technique, which measures the primary interaction between DNA and antibody to DNA, is based on the observation that free DNA is soluble in 50-percent saturated ammonium sulfate whereas antibody-bound DNA is insoluble.read more
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Journal ArticleDOI
Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group.
Peter E. Lipsky,D. van der Heijde,E W St Clair,Daniel E. Furst,F. C. Breedveld,J. R. Kalden,Josef S. Smolen,M Weisman,Paul Emery,Marc Feldmann,Gregory Harriman,Ravinder Nath Maini +11 more
TL;DR: In patients with persistently active rheumatoid arthritis despite methotrexate therapy, repeated doses of infliximab in combination with methotRexate provided clinical benefit and halted the progression of joint damage.
Infliximab and methotrexate in the treatment of rheumatoid arthritis
Book ChapterDOI
Autoantibodies to nuclear antigens (ANA): their immunobiology and medicine.
TL;DR: Autoantibodies to nuclear antigens (ANAs) have assumed an important place in the diagnostic armamentarium of the clinician because of distinct profiles of ANAs in different diseases.
Journal ArticleDOI
Infliximab improves signs and symptoms of psoriatic arthritis: results of the IMPACT 2 trial
C Antoni,Gerald G. Krueger,K. de Vlam,C. Birbara,A. Beutler,Cynthia Guzzo,B. Zhou,Lisa T. Dooley,Arthur Kavanaugh +8 more
TL;DR: Infliximab 5 mg/kg through 24 weeks significantly improved active PsA, including dactylitis and enthesopathy, and associated psoriasis.
Book ChapterDOI
Immune Complex Disease in Experimental Animals and Man
Charles G. Cochrane,D Koffler +1 more
TL;DR: This chapter summarizes the data presented in two reviews of experimental acute and chronic immune complex disease produced by nonliving antigens and discusses in detail more recent studies.
References
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Book
Handbook of experimental immunology
TL;DR: This document describes the development and application of various methods for immunologic studies using monoclonal antibodies, a type of antibody, and some of the methods used in these studies are currently in use.
Journal ArticleDOI
An Improved Diphenylamine Method for the Estimation of Deoxyribonucleic Acid
K. W. Giles,A. Myers +1 more
TL;DR: In this article, the Burton diphenylamine method was used to estimate extreme sensitivity coupled with a low reagent blank, which was simplified and the blank considerably reduced and the sensitivity increased.
Journal ArticleDOI
A quantitative immunochemical measure of the primary interaction between I BSA and antibody.
TL;DR: Most qualitative and quantitative antibody tests measure secondary effects of primary antigen-antibody interactions, but they do not always reflect the total antibody content of the antiserum with respect to the test antigen.
Journal ArticleDOI
Deoxybonucleic acid (DNA) and antibodies to DNA in the serum of patients with systemic lupus erythematosus.
Journal Article
Characteristics of a Soluble Nuclear Antigen Precipitating with Sera of Patients with Systemic Lupus Erythematosus
Eng M. Tan,H. G. Kunkel +1 more
TL;DR: Sera of patients with systemic lupus erythematosus were demonstrated to contain precipitating antibodies to soluble tissue components other than DNA, and one dominant reaction was observed which was provisionally termed the Sm system.