Journal ArticleDOI
Depression of nocturnal pineal serotonin N-acetyltransferase activity in castrate male rats
TLDR
The data substantiate the existence of a feedback control of pineal biosynthetic activity by the hypophyseal-gonadal system, but the identity of the hormone(s) responsible for regulation ofpineal NAT activity is not known.Abstract:
Pineal serotonin N-acetyltransferase (NAT) activity was examined in intact rats, castrated rats, and in rats that had been castrated and had received testosterone proprionate. Castration resulted in significantly depressing nocturnal levels of pineal NAT (p<0.05) when compared to enzyme activity in intact rats. Testosterone proprionate administration restored plasma LH levels to normal values in castrate rats but did not induce nocturnal pineal enzyme activity to levels seen in the pineal glands of intact rats. The data substantiate the existence of a feedback control of pineal biosynthetic activity by the hypophyseal-gonadal system, but the identity of the hormone(s) responsible for regulation of pineal NAT activity is not known.read more
Citations
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Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters
TL;DR: The aim of this review is to gather together early and recent data on the effects of the nonadrenergic transmitters on modulation of melatonin synthesis, which reveals the variety of inputs that can be integrated by the pineal gland; what elements are crucial to deliver the very precise timing information to the organism.
Journal ArticleDOI
What causes mental dysfunction in Parkinson's disease?
TL;DR: Recent evidence suggests that LB‐type degeneration in limbic structures and cerebral cortex, with consequent synaptic and cell loss, is the main pathological state associated with dementia in PD.
Journal ArticleDOI
Cognitive change in Parkinson disease.
TL;DR: The clinical, cognitive, neuropsychiatric features of cognitive deficits associated with PD are examined, their pathologic basis is discussed, and avenues for future research are proposed.
Journal ArticleDOI
Fetal/placental regulation of maternal melatonin in rats.
TL;DR: Maternal circulating melatonin is from the maternal pineal gland and is increased by placental hormones during pregnancy, which is investigated in pregnant rats.
Journal ArticleDOI
The rhythm and blues of gene expression in the rodent pineal gland.
TL;DR: Together, concerted signaling events in the rodent pineal gland help to generate a stable and reliable hormonal message of darkness for the body, that, however, can be altered rapidly upon sudden and unexpected “error” signals.
References
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Book
Computational Handbook of Statistics
James L. Bruning,B. L. Kintz +1 more
TL;DR: In this paper, the authors present an analysis of correlation and correlation coefficients for the Mann-Whitney Test, the Newman-Keuls' and Tukey Mulitple-Comparison Tests, and the Signed-Pairs, Signed-Ranks Test.
Journal ArticleDOI
Indole Metabolism in the Pineal Gland: A Circadian Rhythm in N-Acetyltransferase
David C. Klein,Joan L. Weller +1 more
TL;DR: Experiments in vitro indicate that norepinephrine, not serotonin, regulates the activity of N-acetyl-transferase through a highly specific receptor.
Journal ArticleDOI
Sensitive assay for serotonin N-acetyltransferase activity in rat pineal.
Takeo Deguchi,Julius Axelrod +1 more