Biomedical Importance of Indoles
Nagendra Kumar Kaushik,Neha Kaushik,Pankaj Attri,Naresh Kumar,Chung Hyeok Kim,Akhilesh K. Verma,Eun Ha Choi +6 more
TLDR
Some of the relevant and recent achievements in the biological, chemical and pharmacological activity of important indole derivatives in the areas of drug discovery and analysis are covered.Abstract:
The indole nucleus is an important element of many natural and synthetic molecules with significant biological activity. This review covers some of the relevant and recent achievements in the biological, chemical and pharmacological activity of important indole derivatives in the areas of drug discovery and analysis.read more
Citations
More filters
Journal ArticleDOI
Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals
TL;DR: This review reports on the top 25 most commonly utilized nitrogen heterocycles found in pharmaceuticals, and reports detailed substitution patterns, highlight common architectural cores, and discuss unusual or rare structures.
Journal ArticleDOI
A review on recent developments of indole-containing antiviral agents.
TL;DR: This review focused on the recent development of indole derivatives as antiviral agents and summarized the structure property, hoping to inspire new and even more creative approaches to discover novel drugs with different modes of action.
Journal ArticleDOI
Heterocyclic Anticancer Compounds: Recent Advances and the Paradigm Shift towards the Use of Nanomedicine's Tool Box.
Pedro Martins,João Jesus,Sofia Duque Santos,Luís Raposo,Catarina Roma-Rodrigues,Pedro V. Baptista,Alexandra R. Fernandes,Alexandra R. Fernandes +7 more
TL;DR: This review provides for a concise overview of heterocyclic active compounds and families and their main applications in medicine, focusing on those suitable for cancer therapy while simultaneously addressing main biochemical modes of action, biological targets, structure-activity relationships as well as intrinsic limitation issues in the use of these compounds.
Journal ArticleDOI
Indoles - A promising scaffold for drug development.
T.V. Sravanthi,S. L. Manju +1 more
TL;DR: A clear knowledge is provided on the wide-ranging biological activities of 2-arylindoles over the past two decades, which would be beneficial for the designing of more potent drug targets in order to compete with the existing drugs.
Journal ArticleDOI
Strategies for the asymmetric functionalization of indoles: an update.
TL;DR: This critical review documents the literature on this topic, until the end of 2013, of new synthetic methodologies for the rapid construction of enantiomerically pure substituted indole.
References
More filters
Journal ArticleDOI
The Expanded Biology of Serotonin
TL;DR: New work suggests that serotonin may regulate some processes, including platelet aggregation, by receptor-independent, transglutaminase-dependent covalent linkage to cellular proteins.
Journal ArticleDOI
Indomethacin and aspirin abolish prostaglandin release from the spleen.
TL;DR: The action of these two anti-inflammatory agents provides further support for the suggestion that some of their therapeutic effects depend on the inhibition of the production of prostaglandin.
Journal ArticleDOI
Design and synthesis of conformationally constrained amino acids as versatile scaffolds and peptide mimetics
Journal Article
The Vinca Alkaloids: A New Class of Oncolytic Agents
TL;DR: A phytochemical investigation of the plant Vinca rosea Linn has demonstrated that a number of alkaloidal substances can be obtained with antitumor activity, including vinblastine, vincristine, and vinrosidine, which are capable of prolonging and/or “curing” mice of the P-1534 leukemia.