Journal ArticleDOI
Detection of antithyroid residues in meat and some organs of slaughtered animals.
H.F. De Brabander,R. Verbeke +1 more
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TLDR
A simple method is described for the routine detection of antithyroid residues in thyroid, liver, kidney and meat contaminated at levels as low as 10 ppb (10 parts per 10(9).About:
This article is published in Journal of Chromatography A.The article was published on 1975-05-07. It has received 37 citations till now.read more
Citations
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Journal ArticleDOI
Options for veterinary drug analysis using mass spectrometry.
TL;DR: The present article reviews the main mass spectrometric strategies, from the very first, nonetheless still efficient, single MS and multidimensional and high-resolution MS through to advanced isotope ratio MS, with an emphasis not only on such critical points as ion suppression and resolution, but also on the adequacy of the current regulation regarding the evolution of the technology.
Journal ArticleDOI
Senstitive multi-residue method for detection of anabolics in urine and in tissues of slaughtered animals
TL;DR: A suitable extraction and clean-up procedure was developed, permitting adequate recovery of various anabolics from tissue samples (50 g) or urine (50 ml) and the presence of the anabolic residues are detected by sulphuric acid—induced fluorescence.
Journal ArticleDOI
Past, present and future of mass spectrometry in the analysis of residues of banned substances in meat-producing animals.
H.F. De Brabander,B. Le Bizec,Gaud Pinel,Jean-Philippe Antignac,K. Verheyden,Virginie Mortier,Dirk Courtheyn,Herlinde Noppe +7 more
TL;DR: The past, present and future of mass spectrometry in this area are discussed in the light of the impact of these substances on human health and the reliable production of analytical results, ready for challenge in a court.
Journal ArticleDOI
Determination of mercaptobenzimidazol and other thyreostat residues in thyroid tissue and meat using high-performance liquid chromatography-mass spectrometry.
TL;DR: The solid-phase extraction procedure is optimized to obtain the maximum results for the main thyreostats including MBI, and the identification of the analytes was performed according to the final revision of the EU criteria.
Journal ArticleDOI
Multi-residue method for the determination of thyreostats in urine samples using liquid chromatography coupled to tandem mass spectrometry after derivatisation with 3-iodobenzylbromide.
TL;DR: The analytical procedure involves, after a derivatisation step with 3-iodobenzylbromide, the detection and identification at low level by LC-ESI(-)-MS/MS of eight thyreostats in various biological matrices and the performances fulfil the requirements of the EU regarding the provisional minimum required performance limit (MRPL) fixed at 100 microg/L in urine.
References
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Journal ArticleDOI
7-chloro-4-nitrobenzo-2-oxa-1,3-diazole: a new fluorigenic reagent for amino acids and other amines.
P B Ghosh,Michael W. Whitehouse +1 more
Journal ArticleDOI
Further studies on the chemical nature of compounds which inhibit the function of the thyroid gland11
TL;DR: A more accurate and reproducible method based upon the weight and iodine concentration of the thyroid gland (Astwood & Bissell,1944) has been used in the present investigation.
Journal ArticleDOI
The reactivity of SH groups with a fluorogenic reagent.
TL;DR: NBD-Chloride was synthesised by the method of Boulton et al. and had a m.p. and IR spectrum identical to that reported [2].
Journal Article
The chemical nature of compounds which inhibit the function of the thyroid gland
TL;DR: In this article, the relative effectiveness of 106 chemical compounds in inhibiting the function of the thyroid gland was tested in young rats and two classes of compounds were found to be active: thiourea derivatives and certain derivatives of aniline.