Journal ArticleDOI
Detection of Australia antigen and antibody by means of radioimmunoassay techniques.
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TLDR
It has been shown that the presence of anti-Au does not always prevent the development of hepatitis, and it has been possible to identify Au in some but not all units of blood that have induced hepatitis.Abstract:
Australia antigen (Au) has been identified in the blood of patients with "long-incubation hepatitis" by use of agar-gel diffusion or complement fixation (CF) [1-6]. Characterization of the antigen as a viruslike particle and its localization in the nuclei of liver cells of patients with hepatitis have provided evidence that Au may be the agent of long-incubation hepatitis [7-11]. A precipitating and complement-fixing antibody to Au (anti-Au) has been identified in the serum of patients who have received multiple transfusions but rarely, if ever, in serum from patients convalescing from hepatitis [1-3, 5-12]. It has been shown that the presence of anti-Au does not always prevent the development of hepatitis [13]. Transfusion of blood containing Au may result in hepatitis in the recipient [3, 12]. With agar-gel diffusion, it has been possible to identify Au in some but not all units of blood that have inducedread more
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Book ChapterDOI
Viral Hepatitis A and E
TL;DR: In this article, passive immunization with immune serum globulin provides high level protection against hepatitis A, but effective inactivated vaccines will soon be available for clinical use, but their effectiveness is limited.
References
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Journal ArticleDOI
The preparation of 131i-labelled human growth hormone of high specific radioactivity
TL;DR: The loss of immunological reactivity at high specific radioactivities or at high levels of chemical substitution with STAI/sup 127/!iodine is demonstrated.
Journal ArticleDOI
Immunoassay of endogenous plasma insulin in man
TL;DR: The insulin concentration in plasma has been estimated from the degree of hypoglycemia produced in hypophysectomized, adrenalectomization, alloxan-diabetic rats, and from the increased oxidation of glucose-1-C14 by the rat epididymal fat pad.
Journal ArticleDOI
Insulin-i131 metabolism in human subjects: demonstration of insulin binding globulin in the circulation of insulin treated subjects
Journal ArticleDOI
An antigen detected in the blood during the incubation period of serum hepatitis
TL;DR: An antigen that reacted in the immunodiffusion test with serum from multiply transfused patients was detected in the blood during the incubation period prior to the onset of major chemical or clinical abnormalities, suggesting this antigen is specific for serum hepatitis virus.
Journal ArticleDOI
Particles associated with Australia Antigen in the Sera of Patients with Leukaemia, Down's Syndrome and Hepatitis
TL;DR: The precipitin band which forms between the haemophilia antiserum and the serum containing Australia antigen stains faintly with sudan black, indicating that the antigen contains lipid.
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