Journal ArticleDOI
Detection of Australia antigen and antibody by means of radioimmunoassay techniques.
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It has been shown that the presence of anti-Au does not always prevent the development of hepatitis, and it has been possible to identify Au in some but not all units of blood that have induced hepatitis.Abstract:
Australia antigen (Au) has been identified in the blood of patients with "long-incubation hepatitis" by use of agar-gel diffusion or complement fixation (CF) [1-6]. Characterization of the antigen as a viruslike particle and its localization in the nuclei of liver cells of patients with hepatitis have provided evidence that Au may be the agent of long-incubation hepatitis [7-11]. A precipitating and complement-fixing antibody to Au (anti-Au) has been identified in the serum of patients who have received multiple transfusions but rarely, if ever, in serum from patients convalescing from hepatitis [1-3, 5-12]. It has been shown that the presence of anti-Au does not always prevent the development of hepatitis [13]. Transfusion of blood containing Au may result in hepatitis in the recipient [3, 12]. With agar-gel diffusion, it has been possible to identify Au in some but not all units of blood that have inducedread more
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Journal ArticleDOI
Vertical transmission of hepatitis B antigen in Taiwan.
TL;DR: It is indicated that vertical transmission from carrier mothers frequently occurs, at least in Taiwan, and may partially explain Taiwan's high prevalence of HB5 Ag.
Patent
Process for the demonstration and determination of reaction components having specific binding affinity for each other
TL;DR: In this article, a process for the determination of a component of the reaction between a specific binding protein and the substance being specifically bound by such a protein comprising reacting the component to be determined with its binding partner in an insolubilized form, separating the solid phase of a reaction mixture from the liquid phase, reacting with a determined amount of a coupling product of the substance, and finally determining the enzyme activity of the liquid or solid phase obtained.
Journal ArticleDOI
Hemagglutination Assay for Antigen and Antibody Associated with Viral Hepatitis
Girish N. Vyas,N. R. Shulman +1 more
TL;DR: The hemagglutination test has the sensitivity and rapidity of the best tests available, is simpler to perform, and lends itself to large-scale screening of blood donors.
Journal ArticleDOI
Viral Hepatitis: New Light on an Old Disease
Saul Krugman,Joan P. Giles +1 more
TL;DR: Hepatitis-associated antigen was consistently present in sera from patients with MS-2 strain of serum hepatitis (SH); it was not present in MS-1, infectious hepatitis (IH), and Gamma-globulin consistently neutralized the infectivity of IH (MS-1) serum; in most cases it did not neutralize the infectivities of SH (MS -2) serum.
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Journal ArticleDOI
Relation of Australia-SH antigen to the willowbrook MS-2 strain.
TL;DR: The author diligently records his own feelings about being at the births of three infants whose parents do not know him well but allow him to be present, which compromises his advocacy of "natural" childbirth considerably.
Journal ArticleDOI
Virus-like antigen, antibody, and antigen-antibody complexes in hepatitis measured by complement fixation.
TL;DR: Complement fixation techniques are described for measuring a virus-like antigen associated with viral hepatitis, which was found in the blood of 98 percent of 130 patients, with the serum form of hepatitis, from whom multiple samples were obtained.
Journal ArticleDOI
Observations on Australia antigen in Japanese.
K. Okochi,S. Murakami +1 more
TL;DR: The antigen was not an invariable serum antigen in patients who received blood transfusion and in patients with viral hepatitis, and the antibodies against Australia antigen were found not only in the recipients of Australia antigen positive but also of Australia antibody negative blood.
Journal ArticleDOI
HEPATITIS ANTIGEN: Correlation with Disease and Infectivity of Blood-Donors
DavidJ. Gocke,NeilB. Kavey +1 more
TL;DR: A specific acute-phase antigen has been demonstrated in the sera of patients with viral hepatitis and was found in some blood-donors and correlated with development of hepatitis in recipients of their blood.
Journal ArticleDOI
A complement-fixation test for measuring Australia antigen and antibody.
Robert H. Purcell,Paul V. Holland,John H. Walsh,Doris C. Wong,Andrew G. Morrow,Robert M. Chanock +5 more
TL;DR: The present study describes a complement-fixation (CF) test for the measurement of Au and anti-Au, the relative sensitivity and specificity of the test, and its use in detecting, quantitating, and serologically comparing Au and self-reported antibody to Au.
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