Detection of cross-reactive anti-DNA antibody idiotypes in the serum of systemic lupus erythematosus patients and of their relatives.
David A. Isenberg,Y Shoenfeld,Mark Walport,C G Mackworth-Young,C. Dudeney,A Todd-Pokropek,S. Brill,A. Weinberger,J. Pinkas +8 more
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TLDR
Two common cross-reacting anti-DNA antibody idiotypes designated 16/6 and 32/15, previously identified in the serum of patients who have systemic lupus erythematosus, were found in 147 first-degree relatives, implying that high-frequency germ-line genes exist among l upus relatives, as well as patients.Abstract:
Two common cross-reacting anti-DNA antibody idiotypes designated 16/6 and 32/15, previously identified in the serum of patients who have systemic lupus erythematosus, were found in 24% and 7%, respectively, of 147 first-degree relatives. These findings imply that high-frequency germ-line genes exist among lupus relatives, as well as patients. These dominant or public anti-DNA antibody idiotypes are not likely to be pathogenic factors, but are probably a genetically associated phenomenon.read more
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Systemic lupus erythematosus
Jessica J Manson,Anisur Rahman +1 more
TL;DR: Systemic lupus erythematosus is a relapsing and remitting disease, and treatment aims are threefold: managing acute periods of potentially life-threatening ill health, minimizing the risk of flares during periods of relative stability, and controlling the less life- threatening, but often incapacitating day to day symptoms.
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Assessment of antibodies to double‐stranded DNA induced in rheumatoid arthritis patients following treatment with infliximab, a monoclonal antibody to tumor necrosis factor α: Findings in open‐label and randomized placebo‐controlled trials
TL;DR: Anti-dsDNA antibodies of IgM class are induced by infliximab therapy; the frequency is dependent on the assay method used.
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The mosaic of autoimmunity.
C M Brickman,Yehuda Shoenfeld +1 more
TL;DR: A brief review of immunobiology in order to arrive at a suitable definition of auto-immunity is given in this paper, followed by a concise description of the current theories regarding the development of autoimmune disease and the factors known to be associated with these illnesses.
Journal ArticleDOI
Polymorphism at the C-reactive protein locus influences gene expression and predisposes to systemic lupus erythematosus
Andrew Russell,Deborah S. Cunninghame Graham,Christopher J. Shepherd,Cheri A. Roberton,John C. Whittaker,John Meeks,Richard J Powell,David A. Isenberg,Mark Walport,Timothy J. Vyse +9 more
TL;DR: The hypothesis that defective disposal of potentially immunogenic material is a contributory factor in lupus pathogenesis is supported and the identification of polymorphisms that determine basal CRP levels has implications in ischaemic heart disease, where CRP level is an important predictor of risk.
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Interleukin–1 receptor antagonist gene polymorphism as a disease severity factor in systemic lupus erythematosus
Alexandra I. F. Blakemore,Joanna K. Tarlow,Michael J. Cork,Caroline Gordon,Paul Emery,Gordon W. Duff +5 more
TL;DR: It is postulate that the association of this polymorphism with disease severity is a widespread feature of common inflammatory and autoimmune diseases.
References
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The 1982 revised criteria for the classification of systemic lupus erythematosus
Eng M. Tan,Alan S. Cohen,James F. Fries,Alfonse T. Masi,Dennis J. McShane,Naomi F. Rothfield,Jane G. Schaller,Norman Talal,Robert Winchester +8 more
TL;DR: The 1971 preliminary criteria for the classification of systemic lupus erythematosus (SLE) were revised and updated to incorporate new immunologic knowledge and improve disease classification and showed gains in sensitivity and specificity.
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The natural history of systemic lupus erythematosus by prospective analysis.
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Polyspecific monoclonal lupus autoantibodies reactive with both polynucleotides and phospholipids
Eileen M. Lafer,J Rauch,Chester Andrzejewski,D. Mudd,Bruce Furie,Robert S. Schwartz,B D Stollar +6 more
TL;DR: The polyspecific reactivity of a single molecular species of lupusAutoantibody suggests that some of the diverse serological abnormalities of SLE may be a result of the binding of certain autoantibodies to a phosphodiester-containing epitope that is present in diverse biological molecules.
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Family study of the major histocompatibility complex in patients with systemic lupus erythematosus: importance of null alleles of C4A and C4B in determining disease susceptibility.
A. H. L. Fielder,Mark Walport,J. R. Batchelor,R. I. Rynes,Carol M. Black,I. A. Dodi,Grv Hughes +6 more
TL;DR: The known association of systemic lupus erythematosus with uncommon inherited and acquired deficiencies of complement components suggests, however, that the presence of null alleles for C4A and C4B, as well as C2, found in most of the patients, is relevant to their genetic susceptibility to this disease.
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Polyspecificity of Monoclonal Lupus Autoantibodies Produced by Human-Human Hybridomas
Yehuda Shoenfeld,J Rauch,Massicotte H,S K Datta,Janine André-Schwartz,B D Stollar,Robert S. Schwartz +6 more
TL;DR: The findings suggest that DNA itself need not be the immunogenic stimulus for autoantibody formation in systemic lupus erythematosus, and may be explained by the presence of appropriately spaced phosphodiester groups in both the polynucleotides and the phospholipid.