Detection of endotoxin in human blood and demonstration of an inhibitor
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TLDR
The increase in positive tests, following dilution or chloroform extraction of serum or plasma, suggested that the inhibitory nature of blood is primarily the result of reversible binding between endotoxin and serum protein(s), rather than destruction of endotoxin.About:
This article is published in Journal of Laboratory and Clinical Medicine.The article was published on 1970-06-01 and is currently open access. It has received 421 citations till now. The article focuses on the topics: Whole blood & Amebocyte.read more
Citations
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Journal ArticleDOI
An endotoxin-induced serum factor that causes necrosis of tumors
TL;DR: It is proposed that TNF mediates endotoxin-induced tumor necrosis, and that it may be responsible for the suppression of transformed cells by activated macrophages.
Journal ArticleDOI
Endotoxemia in human septic shock.
Robert L. Danner,Ronald J. Elin,Jeanette M. Hosseini,Robert Wesley,Joseph M. Reilly,Joseph E. Parillo +5 more
TL;DR: It is suggested that endotoxin is an important mediator of septic shock and supports efforts to develop anti-endotoxin therapies for treating patients with this disease.
Journal ArticleDOI
Expression of the nitric oxide synthase gene in mouse macrophages activated for tumor cell killing. Molecular basis for the synergy between interferon-gamma and lipopolysaccharide.
TL;DR: Results here show that synthesis of nitric oxide (NO) was greatly increased when cells of the mouse macrophage cell line RAW 264.7 were costimulated with bacterial lipopolysaccharide (LPS) and interferon-gamma (IFN-Gamma) and LPS, compared to LPS alone, which paralleled increases in cytotoxicity.
Journal ArticleDOI
Plasma Endotoxin as a Predictor of Multiple Organ Failure and Death in Systemic Meningococcal Disease
Petter Brandtzaeg,Peter Kierulf,Peter Gaustad,Andreas Skulberg,Johan N. Bruun,Sverre Halvorsen,Eigil Sørensen +6 more
TL;DR: Observations suggest that LOS quantitation using the limulus amebocyte lysate assay with a chromogenic substrate gives important progsnotic information and may provide new insight concerning pathophysiological aspects of SMD.
Journal ArticleDOI
Plasma (1→3)-β-D-glucan measurement in diagnosis of invasive deep mycosis and fungal febrile episodes
T Obayashi,Tadashi Kawai,Minoru Yoshida,Takeshi Mori,Hajime Goto,A Yasuoka,Kaoru Shimada,H Iwasaki,H Teshima,Shigeru Kohno,A Horiuchi,Akira Ito,Hisateru Yamaguchi +12 more
TL;DR: Determination of plasma (1-->3)-beta-D-glucan with factor G is a highly sensitive and specific test for invasive deep mycosis and fungal febrile episodes, and will substantially benefit immunocompromised patients.
References
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Journal ArticleDOI
Immunochemistry of O and R antigens of Salmonella and related Enterobacteriaceae.
O. Lüderitz,A M Staub,Westphal O +2 more
TL;DR: Preparation and Composition of R (Lipo)polysaccharides and Biochemical and Genetic Basis of Changes in Specificity After Phage Conversion.
Journal ArticleDOI
Clottable protein in Limulus; its localization and kinetics of its coagulation by endotoxin.
TL;DR: The clottable protein in lysates of amebocytes has a spectral absorption pattern with a maximum at 270-275 mμ, appears to have a low sedimentation coefficient, is stable at −20°C for 1 week, and is destroyed by heating at 56° C for 30 min this article.
Journal Article
The role of endotoxin in the extracellular coagulation of limulus blood.
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