Development and first validation of the COPD Assessment Test
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TLDR
The aim of the present study was to develop a short validated patient-completed questionnaire, the COPD Assessment Test (CAT), assessing the impact of COPD on health status, which has good measurement properties, is sensitive to differences in state and should provide a valid, reliable and standardised measure of COPd health status with worldwide relevance.Abstract:
There is need for a validated short, simple instrument to quantify chronic obstructive pulmonary disease (COPD) impact in routine practice to aid health status assessment and communication between patient and physician. Current health-related quality of life questionnaires provide valid assessment of COPD, but are complex, which limits routine use. The aim of the present study was to develop a short validated patient-completed questionnaire, the COPD Assessment Test (CAT), assessing the impact of COPD on health status. 21 candidate items identified through qualitative research with COPD patients were used in three prospective international studies (Europe and the USA, n51,503). Psychometric and Rasch analyses identified eight items fitting a unidimensional model to form the CAT. Items were tested for differential functioning between countries. Internal consistency was excellent: Cronbach's a50.88. Test re-test in stable patients (n553) was very good (intra-class correlation coefficient 0.8). In the sample from the USA, the correlation with the COPD-specific version of the St George's Respiratory Questionnaire was r50.80. The difference between stable (n5229) and exacerbation patients (n567) was five units of the 40-point scale (12%; p,0.0001). The CAT is a short, simple questionnaire for assessing and monitoring COPD. It has good measurement properties, is sensitive to differences in state and should provide a valid, reliable and standardised measure of COPD health status with worldwide relevance.read more
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Validation of the COPD Assessment Test (CAT) as an Outcome Measure in Bronchiectasis
TL;DR: CAT is a valid, responsive symptom assessment tool in bronchiectasis and the minimum clinically important difference (MCID) is calculated using a combination of distribution and anchor based methods.
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A randomised, open-label study of umeclidinium versus glycopyrronium in patients with COPD
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Impact of a Single Session of Inhalation Technique Training on Inhalation Skills and the Course of Asthma and COPD.
Marta Dabrowska,Katarzyna Luczak-Wozniak,Marta Miszczuk,Izabela Domagała,Wojciech Lubanski,Andrzej Leszczynski,Marta Maskey-Warzęchowska,Renata Rubinsztajn,Joanna Hermanowicz-Salamon,Rafał Krenke +9 more
TL;DR: Although a single inhalation training leads to a reduction in the number of errors made during inhalation, it does not influence the course of asthma and COPD and the positive effect of asingle inhalation technique training is temporary.
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Deterioration of Nighttime Respiratory Mechanics in COPD: Impact of Bronchodilator Therapy.
Nicolle J. Domnik,Matthew D. James,Robin E. Scheeren,Grace A. Ayoo,Sarah M. Taylor,Amanda T. Di Luch,Kathryn M. Milne,Sandra G. Vincent,Devin B. Phillips,Amany F. Elbehairy,Amany F. Elbehairy,Sophie J. Crinion,Helen S. Driver,J. Alberto Neder,Denis E. O'Donnell +14 more
TL;DR: While morning trough IC was unchanged, evening bronchodilator treatment was consistently associated with sustained overnight improvements in dynamic respiratory mechanics and inspiratory neural drive compared with placebo.
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Exercise capacity impairment in COPD patients with comorbidities.
G. Da Silva,M.T.A. Pessoa Morano,A.G. De Matos Cavalcante,N.M. De Andrade,E. De Francesco Daher,Eanes Delgado Barros Pereira +5 more
TL;DR: The presence of comorbidities contributed to impair exercise capacity in patients with COPD in a cross-sectional study conducted at two teaching hospitals in Fortaleza, Brazil.
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