Journal ArticleDOI
Diabetic cardiomyopathy: How can cardiac magnetic resonance help?
TLDR
The aim of this review was to summarize the current knowledge and clinical usefulness of CMR in diabetic patients and show a strong correlation between ECV—parameter of interstitial fibrosis and level of glycated hemoglobin—main parameter of glucose control in diabetes.Abstract:
Diabetes cardiomyopathy is a specific form of cardiac disease characteristic for diabetic patients. Development of echocardiography enabled diagnosis of diabetic cardiomyopathy significantly before the occurrence of heart failure. Previously was believed that left ventricular (LV) diastolic dysfunction represents the first detectable stage of diabetic cardiomyopathy. However, speckle tracking imaging and strain evaluation showed that mechanical changes occur before LV diastolic dysfunction. Nevertheless, it seems that the first detectable stage of diabetic cardiomyopathy is myocardial interstitial fibrosis, which currently could be diagnosed predominantly by cardiac magnetic resonance. T1 mapping evaluation before and after contrast injection enables assessment of extracellular volume (ECV) and provides qualitative and quantitative assessment of interstitial myocardial fibrosis in diabetic patients. Studies showed a strong correlation between ECV-parameter of interstitial fibrosis and level of glycated hemoglobin-main parameter of glucose control in diabetes. This stage of fibrosis is still not LV hypertrophy and it is reversible, which is of a great importance because of timely initiation of treatment. The necessity for early diagnose is significantly increasing due to the fact that diabetes and arterial hypertension are concomitant disorders in the large number of diabetic patients and it has been known that the risk of interstitial myocardial fibrosis is multiplied in patients with both conditions. Future follow-up investigations are essential to determine the causal relationship between interstitial fibrosis and outcome in these patients. The aim of this review was to summarize the current knowledge and clinical usefulness of CMR in diabetic patients.read more
Citations
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Journal ArticleDOI
Assessment of subclinical diabetic cardiomyopathy by speckle-tracking imaging.
Ioan-Alexandru Minciuna,Olga Hilda Orășan,Iulia Minciuna,Andrada-Luciana Lazar,Adela Sitar-Taut,Monica Oltean,Raluca Tomoaia,Mihai Puiu,Dan-Andrei Sitar-Taut,Dana Pop,Angela Cozma +10 more
TL;DR: Whether subclinical myocardial systolic dysfunction appears ahead of diastolic dysfunction and the implication this may have on the evolution and management of DCM is reviewed.
Journal ArticleDOI
The association of the metabolic syndrome with target organ damage: focus on the heart, brain, and central arteries
TL;DR: The present review gives an update on the definition and prevalence of MetS, and its impact on cardiac structure and function as well as on the brain and central arteries.
Journal ArticleDOI
The Role of Mitochondrial Abnormalities in Diabetic Cardiomyopathy
Siarhei A. Dabravolski,Nikolay K. Sadykhov,Andrey G. Kartuesov,E. Borisov,Vasily N. Sukhorukov,Alexander N. Orekhov +5 more
TL;DR: This review focuses on the role of mitochondrial dynamics, biogenesis and mitophagy, Ca2+ metabolism and bioenergetics in the DCM development and progression and proposes strategies to slow down the progression of the disease.
Journal ArticleDOI
Aggravation of functional mitral regurgitation on left ventricle stiffness in type 2 diabetes mellitus patients evaluated by CMR tissue tracking.
TL;DR: In this article, the authors investigated the effect of functional mitral regurgitation (FMR) on the deterioration of left ventricular (LV) strain in type 2 diabetes mellitus (T2DM) patients and explore the independent indicators of LV peak strain (PS).
Journal ArticleDOI
Rutin alleviates cardiomyocyte injury induced by high glucose through inhibiting apoptosis and endoplasmic reticulum stress.
TL;DR: In this paper, the effect of rutin on myocardial injury caused by diabetes from the perspective of endoplasmic reticulum stress (ERS) has been investigated and shown to be beneficial.
References
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Journal ArticleDOI
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Journal ArticleDOI
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TL;DR: It is postulated that the myocardial disease seen in these cases is probably secondary to diabetic mjcroangiopathy although the direct effects of the abnormalMyocardial metabolism in diabetes could not be excluded.
Journal ArticleDOI
Clinical recommendations for cardiovascular magnetic resonance mapping of T1, T2, T2 and extracellular volume: A consensus statement by the Society for Cardiovascular Magnetic Resonance (SCMR) endorsed by the European Association for Cardiovascular Imaging (EACVI)
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Journal ArticleDOI
A Test in Context: Myocardial Strain Measured by Speckle-Tracking Echocardiography
TL;DR: This review appraised speckle-tracking echocardiography in a clinical context by providing a critical evaluation of the prognostic and diagnostic insights that this technology can provide.
Journal ArticleDOI
Reference values for healthy human myocardium using a T1 mapping methodology: results from the International T1 Multicenter cardiovascular magnetic resonance study
Darius Dabir,Nicholas Child,Ashwin Kalra,Toby Rogers,Rolf Gebker,Andrew Jabbour,Sven Plein,Chung-Yao Yu,James Otton,Ananth Kidambi,Adam K McDiarmid,David A. Broadbent,David M. Higgins,Bernhard Schnackenburg,Lucy Foote,Ciara Cummins,Eike Nagel,Valentina O. Puntmann +17 more
TL;DR: This work shows transferability for a unifying T1 mapping methodology in a multicenter setting and provides reference ranges for T1 values in healthy human myocardium, which can be applied across participating sites.
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