Journal ArticleDOI
Diagnostic Performance of Digital versus Film Mammography for Breast-Cancer Screening
Etta D. Pisano,Constantine Gatsonis,Edward Hendrick,Martin J. Yaffe,Janet K. Baum,Suddhasatta Acharyya,Emily F. Conant,Laurie L. Fajardo,Lawrence W. Bassett,Roberta A. Jong,Murray Rebner +10 more
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The overall diagnostic accuracy of digital and film mammography as a means of screening for breast cancer is similar, but digital mammography is more accurate in women under the age of 50 years, women with radiographically dense breasts, and premenopausal or perimenopausal women.Abstract:
background Film mammography has limited sensitivity for the detection of breast cancer in women with radiographically dense breasts. We assessed whether the use of digital mammography would avoid some of these limitations. methods A total of 49,528 asymptomatic women presenting for screening mammography at 33 sites in the United States and Canada underwent both digital and film mammography. All relevant information was available for 42,760 of these women (86.3 percent). Mammograms were interpreted independently by two radiologists. Breast-cancer status was ascertained on the basis of a breast biopsy done within 15 months after study entry or a follow-up mammogram obtained at least 10 months after study entry. Receiver-operating-characteristic (ROC) analysis was used to evaluate the results. results In the entire population, the diagnostic accuracy of digital and film mammography was similar (difference between methods in the area under the ROC curve, 0.03; 95 percent confidence interval, i0.02 to 0.08; P=0.18). However, the accuracy of digital mammography was significantly higher than that of film mammography among women under the age of 50 years (difference in the area under the curve, 0.15; 95 percent confidence interval, 0.05 to 0.25; P=0.002), women with heterogeneously dense or extremely dense breasts on mammography (difference, 0.11; 95 percent confidence interval, 0.04 to 0.18; P=0.003), and premenopausal or perimenopausal women (difference, 0.15; 95 percent confidence interval, 0.05 to 0.24; P=0.002). conclusions The overall diagnostic accuracy of digital and film mammography as a means of screening for breast cancer is similar, but digital mammography is more accurate in women under the age of 50 years, women with radiographically dense breasts, and premenopausal or perimenopausal women. (clinicaltrials.gov number, NCT00008346.)read more
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Journal ArticleDOI
Mammographic Density and the Risk and Detection of Breast Cancer
Norman F. Boyd,Helen Guo,Lisa J. Martin,Limei Sun,Jennifer Stone,Eve Fishell,Roberta A. Jong,Greg Hislop,Anna M. Chiarelli,Salomon Minkin,Martin J. Yaffe +10 more
TL;DR: Extensive mammographic density is strongly associated with the risk of breast cancer detected by screening or between screening tests, and a substantial fraction of breast cancers can be attributed to this risk factor.
NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines
TL;DR: Lymphedema is a common complication after treatment for breast cancer and factors associated with increased risk of lymphedEMA include extent of axillary surgery, axillary radiation, infection, and patient obesity.
Journal ArticleDOI
International evaluation of an AI system for breast cancer screening.
Scott Mayer McKinney,Marcin Sieniek,Varun Godbole,Jonathan Godwin,Natasha Antropova,Hutan Ashrafian,Trevor Back,Mary Chesus,Greg C. Corrado,Ara Darzi,Mozziyar Etemadi,Florencia Garcia-Vicente,Fiona J. Gilbert,Mark D. Halling-Brown,Demis Hassabis,Sunny Jansen,Alan Karthikesalingam,Christopher Kelly,Dominic King,Joseph R. Ledsam,David S. Melnick,Hormuz Mostofi,Lily Peng,Joshua J. Reicher,Bernardino Romera-Paredes,Richard Sidebottom,Mustafa Suleyman,Daniel Tse,Kenneth C. Young,Jeffrey De Fauw,Shravya Shetty +30 more
TL;DR: A robust assessment of the AI system paves the way for clinical trials to improve the accuracy and efficiency of breast cancer screening and using a combination of AI and human inputs could help to improve screening efficiency.
Journal ArticleDOI
Screening for Breast Cancer: US Preventive Services Task Force Recommendation Statement
Ned Calonge,Diana B. Petitti,Thomas G. DeWitt,Allen J. Dietrich,Kimberly D. Gregory,David C. Grossman,George Isham,Michael L. LeFevre,Rosanne M. Leipzig,Lucy N. Marion,Bernadette Mazurek Melnyk,Virginia A. Moyer,Judith K. Ockene,George F. Sawaya,J. Sanford Schwartz,Timothy J Wilt,US Preventive Serv Task Force +16 more
TL;DR: The USPSTF concludes that the current evidence is insufficient to assess additional benefits and harms of either digital mammography or magnetic resonance imaging instead of film mammography as screening modalities for breast cancer.
Journal ArticleDOI
Screening for Breast Cancer: U.S. Preventive Services Task Force Recommendation Statement
TL;DR: The USPSTF concludes that the current evidence is insufficient to assess the benefits and harms of digital breast tomosynthesis (DBT) as a primary screening method for breast cancer.
References
More filters
Journal ArticleDOI
Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach.
TL;DR: A nonparametric approach to the analysis of areas under correlated ROC curves is presented, by using the theory on generalized U-statistics to generate an estimated covariance matrix.
Journal ArticleDOI
Projecting Individualized Probabilities of Developing Breast Cancer for White Females Who Are Being Examined Annually
Mitchell H. Gail,Louise A. Brinton,David P. Byar,Donald K. Corle,Sylvan B. Green,Catherine Schairer,John J. Mulvihill +6 more
TL;DR: To assist in medical counseling, a method to estimate the chance that a woman with given age and risk factors will develop breast cancer over a specified interval is presented and individualized breast cancer probabilities are calculated.
Journal ArticleDOI
Breast imaging reporting and data system (BI-RADS).
TL;DR: The Breast Imaging Reporting and Data System (BI-RADS) lexicon was developed by the American College of Radiology to standardize mammographic reporting and is clinically useful and facilitates communication and research.
BookDOI
Statistical Methods in Diagnostic Medicine
TL;DR: This book discusses the design of Diagnostic Accuracy Studies, the construction of a Smooth ROC Curve, and how to select a Sampling Plan for Readers based on Sensitivity and Specificity.
Journal ArticleDOI
Breast Cancer Screening: A Summary of the Evidence for the U.S. Preventive Services Task Force
TL;DR: The goal was to critically appraise and synthesize evidence about the overall effectiveness of breast cancer screening, as well as its effectiveness among women younger than 50 years of age, and to evaluate previous meta-analyses of these trials and of screening test characteristics and studies evaluating the harms associated with false-positive test results.