Journal ArticleDOI
Diagnostic Tools and Imaging Methods in Intervertebral Disk Degeneration
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TLDR
New and evolving MRI disk-imaging techniques, including grading, relaxation-time measurements, diffusion, and contrast perfusion, and high-resolution magic-angle spinning methods to correlate in vitro disk degeneration (with pain, etc) and in vivo spectroscopic results are discussed.About:
This article is published in Orthopedic Clinics of North America.The article was published on 2011-10-01. It has received 26 citations till now. The article focuses on the topics: Intervertebral disk.read more
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Journal Article
Low back pain associated with lumbar disc herniation: role of moderately degenerative disc and annulus fibrous tears.
TL;DR: In this paper, the authors explored the characteristic changes of a herniated disc causing low back pain on MRI and clarified the underlying role of inflammatory mediators and annulus fibrous (AF) tears in LBP generation associated with disc herniation.
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Morphology of the Cartilaginous Endplates in Human Intervertebral Disks with Ultrashort Echo Time MR Imaging
Won C. Bae,Sheronda Statum,Zhao Zhang,Tomonori Yamaguchi,Tanya Wolfson,Anthony Gamst,Jiang Du,Graeme M. Bydder,Koichi Masuda,Christine B. Chung +9 more
TL;DR: Ulashort TE imaging, unlike proton density-weighted SE imaging, enabled direct visualization of the uncalcified and calcified CEP at magnetic resonance imaging, and provides opportunities to potentially aid in the understanding of degenerative disk disease.
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Link N and mesenchymal stem cells can induce regeneration of the early degenerate intervertebral disc.
TL;DR: The results support the concept that biological repair of disc degeneration is feasible, and that the administration of either MSCs or Link N has therapeutic potential in early stages of the disease.
Original Article Low back pain associated with lumbar disc herniation: role of moderately degenerative disc and annulus fibrous tears
TL;DR: The high expression of inflammatory mediators with AF tears causes LBP associated with disc herniation, and Moderately degenerative disc with HIZ is MRI morphological change of herniated disc causing LBP, which can be applied to diagnose LBP.
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In vivo diffusion MRS investigation of non-water molecules in biological tissues.
TL;DR: With advances in MRI hardware and diffusion methodology, diffusion MRS of non‐water molecules is expected to provide increasingly valuable and biologically specific information on tissue microstructures and physiology, complementing the traditional diffusion MRI of small and ubiquitous water molecules.
References
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Journal ArticleDOI
Magnetic resonance classification of lumbar intervertebral disc degeneration.
TL;DR: Disc degeneration can be graded reliably on routine T2-weighted magnetic resonance images using the grading system and algorithm presented in this investigation.
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Imaging of degenerative disk disease.
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An Overview of the Incidences and Costs of Low Back Pain
TL;DR: The future challenge, if costs are to be controlled, appears to lie squarely with prevention and optimum management of disability, rather than perpetrating a myth that low back pain is a serious health disorder.
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A study of computer-assisted tomography. I. The incidence of positive CAT scans in an asymptomatic group of patients.
TL;DR: To study the type and number of CAT scan abnormalities of the lumbar spine that occur in asymptomatic people, 52 studies from a control population with no history of back trouble were mixed randomly with six scans from patients with surgically proven spinal disease, and all were interpreted by three neuroradiologists in a blinded fashion.
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Innervation of "painful" lumbar discs.
TL;DR: Findings indicate a more extensive disc innervation in the severely degenerated human lumbar disc compared with normal discs, which provides further evidence for the existence of a morphologic substrate of discogenic pain.