Dietary folate and vitamin B12 intake and cognitive decline among community-dwelling older persons.
Martha Clare Morris,Denis A. Evans,Julia L. Bienias,Christine C. Tangney,Liesi E. Hebert,Paul A. Scherr,Julie A. Schneider +6 more
TLDR
High intake of folate may be associated with cognitive decline in older persons, and these unexpected findings call for further study of the cognitive implications of high levels of dietary folate in older populations.Abstract:
Results: High folate intake was associated with a faster rate of cognitive decline in mixed models adjusted for multiple risk factors. The rate of cognitive decline among persons in the top fifth of total folate intake (median, 742 µg/d) was more than twice that of those in the lowest fifth of intake (median, 186 µg/d), a statistically significant difference of 0.02 standardized unit per year (P=.002). A faster rate of cognitive decline was also associated with high folate intake from food (P for trend=.04) and with folate vitamin supplementation of more than 400 µg/d compared with nonusers (=�.03, P.001). High total B12 intake was associated with slower cognitive decline only among the oldest participants. Conclusions: High intake of folate may be associated with cognitive decline in older persons. These unexpected findings call for further study of the cognitive implications of high levels of dietary folate in older populations.read more
Citations
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Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial.
Jane Durga,Martin P.J. van Boxtel,Evert G. Schouten,Frans J. Kok,Jelle Jolles,Martijn B. Katan,Petra Verhoef +6 more
TL;DR: Folic acid supplementation for 3 years significantly improved domains of cognitive function that tend to decline with age, particularly in memory and sensorimotor speed.
Journal ArticleDOI
Systematic review: factors associated with risk for and possible prevention of cognitive decline in later life.
TL;DR: Few potentially beneficial factors were identified from the evidence on risk or protective factors associated with cognitive decline, but the overall quality of the evidence was low.
Journal ArticleDOI
Is folic acid good for everyone
TL;DR: Nations considering fortification should be cautious and stimulate further research to identify the effects, good and bad, caused by a high intake of folic acid from fortified food or dietary supplements.
Journal ArticleDOI
Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification.
TL;DR: In seniors with low vitamin B-12 status, high serum folate was associated with anemia and cognitive impairment when vitamin B -12 status was normal; when it was normal, however, high Serum folatewas associated with protection against cognitive impairment.
Journal ArticleDOI
Unmetabolized Folic Acid in Plasma Is Associated with Reduced Natural Killer Cell Cytotoxicity among Postmenopausal Women
Aron M. Troen,Breeana L. Mitchell,Breeana L. Mitchell,Bess Sorensen,Mark H. Wener,Abbey Johnston,Brent L. Wood,Jacob Selhub,Anne McTiernan,Yutaka Yasui,Evrim Oral,Evrim Oral,John D. Potter,John D. Potter,Cornelia M. Ulrich,Cornelia M. Ulrich +15 more
TL;DR: An inverse relation between the presence of unmetabolized FA in plasma and NK cytotoxicity was found, and the need for further studies on the effect of long-term high FA intake on immune function and health is highlighted.
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