Journal ArticleDOI
Diethylstilboestrol: I, Pharmacology, Toxicology and carcinogenicity in humans.
Marios Marselos,L. Tomatis +1 more
Reads0
Chats0
TLDR
There is some evidence that administration of diethylstilboestrol in large doses to adult women during pregnancy increases the risk of subsequent breast cancer and it probably increases the incidence of endometrial carcinoma, as has been shown with other similar oestrogens given chronically for menopausal symptoms.About:
This article is published in European Journal of Cancer.The article was published on 1992-05-01. It has received 139 citations till now. The article focuses on the topics: Environmental exposure & Breast cancer.read more
Citations
More filters
Journal ArticleDOI
Diethylstilbestrol revisited: a review of the long-term health effects.
TL;DR: The current information about the health effects related to DES exposure is summarized and screening guidelines for persons exposed to DES are suggested.
Journal ArticleDOI
The antioxidant neuroprotective effects of estrogens and phenolic compounds are independent from their estrogenic properties.
Bernd Moosmann,Christian Behl +1 more
TL;DR: The results call into question the idea of a general correlation between the intended pharmacological effects of estrogens and phenolic compounds and their effect on estrogen receptor-dependent pathways and may open the door toward the rational design of neuroprotective antioxidants with decreased hormonal side effects.
Journal ArticleDOI
To ERR in the estrogen pathway.
TL;DR: Results obtained using the estrogen-related receptors (ERR alpha, -beta and -gamma) have shown that the ERRs share target genes, coregulatory proteins, ligands and sites of action with the ERs, suggesting that pharmacological modulation of ERR activity will be clinically useful to prevent and/or treat a variety of conditions related to women's health.
Journal ArticleDOI
The xenoestrogen bisphenol A induces growth, differentiation, and c-fos gene expression in the female reproductive tract
Rosemary Steinmetz,Natasha A. Mitchner,Andrea Grant,Donald L. Allen,Robert M. Bigsby,Nira Ben-Jonathan +5 more
TL;DR: The studies demonstrate that the molecular and morphological alterations induced by BPA in the uterus and vagina are nearly identical to those induced by estradiol; the vagina appears to be especially sensitive to the estrogenic actions of BPA.
Journal ArticleDOI
Rapid screening of environmental chemicals for estrogen receptor binding capacity
TL;DR: A novel fluorescence polarization (FP) method that measures the capacity of a competitor chemical to displace a high affinity fluorescent ligand from purified, recombinant human ER-[alpha] at room temperature shows promise as a high throughput screening method for large-scale testing of environmental and industrial chemicals for ER binding interactions.
References
More filters
Journal ArticleDOI
Adenocarcinoma of the vagina. Association of maternal stilbestrol therapy with tumor appearance in young women.
TL;DR: The association between treatment of the mothers with estrogen diethylstilbestrol during the pregnancies and the development of adenocarcinoma of the vagina in the girls is highly significant and non-significant factors include maternal age at time of birth smoking in parents intrauterine x-ray exposure and breast feeding.
Journal ArticleDOI
Synthetic œstrogenic agents without the phenanthrene nucleus
E. C. Dodds,W. Lawson +1 more
TL;DR: In this paper, the preparation and physiological properties of synthetic strogenic agents were first described in these columns and elsewhere, and the active compounds described were derivatives of phenanthrene or 1:2:5:6-dibenzanthracene.
Journal ArticleDOI
Adenocarcinoma of the vagina in adolescence. A report of 7 cases including 6 clear-cell carcinomas (so-called mesonephromas).
TL;DR: Seven cases of adenocarcinoma of the vagina occurring in young women 15 to 22 years of age are reported and radical surgery with vaginal replacement and ovarian conservation appears to have been a safe and effective method of therapy.
Journal ArticleDOI
Risk factors for cancer of the testis in young men.
TL;DR: An individually matched case‐control study of testis cancer in 131 men under age 40 was counducted to investigate antecedent risk factors including events during prenatal life, and a hypothesis linking these three factors is presented.