Showing papers in "European Journal of Cancer in 1992"

TL;DR: The results clearly confirm the presence of efficient immunological antitumour defence mechanisms in human breast cancer and tumour-host interactions are subject to further studies particularly in axillary lymph-node negative breast cancer.

TL;DR: A (modified) radical mastectomy was compared with breast-conserving therapy (BCT) in stage I and stage II breast cancer patients and results of salvage treatment for local recurrence so far were similar in both the BCT and the mastectomy group.

TL;DR: In this article, the axillary nodal status at the primary operation for breast cancer was evaluated in 13,851 patients registered by the Danish Breast Cancer Cooperative Group (DBCG).

TL;DR: There were relatively large interindividual differences with respect to salivary flow and discomfort of dryness and it is obvious that these patients need a careful dose planning and a close follow up with co-operation between radiotherapeutists and dentists.

TL;DR: Clinical data are re-analysed to provide evidence for the existence of individual differences in the radiation response of human skin, both for early and late effects.

TL;DR: Routine follow-up is rarely indicated beyond the third year after completion of treatment, or in patients for whom the authors have little to offer in terms of curative treatment, so more time should be spent on training patients to recognise symptoms and signs of recurrence.

TL;DR: There was a significant relationship between prominent reactivity and node status, and the differences between in situ and invasive carcinomas, suggests that TGF-beta 1 may be a determining factor for invasion and metastasis.

TL;DR: Patients in this series with intraductal carcinoma treated with excision and radiation recurred locally at a statistically higher rate than those treated with mastectomy, in spite of the fact that those chosen for excison and radiation had clinically more favourable lesions.

TL;DR: There is some evidence that administration of diethylstilboestrol in large doses to adult women during pregnancy increases the risk of subsequent breast cancer and it probably increases the incidence of endometrial carcinoma, as has been shown with other similar oestrogens given chronically for menopausal symptoms.

TL;DR: 135 consecutive patients aged over 70 years with operable primary breast cancer were randomised to either wedge mastectomy or tamoxifen 20 mg twice daily as initial therapy, with no difference in overall survival or cause of death.

TL;DR: In the present study KPS and ECOG scores were compared in 150 consecutive cancer patients and an empirical relation was established through regression analysis in a subsample of 75 patients and the results tested in the second subsample.

TL;DR: Although in pure DCIS c-erbB-2 positively appears to be associated with tumours with a greater invasive potential, and c- Derbyshire negativity with tumour having a more favourable prognosis, the latter is not necessarily true in infiltrating disease.

TL;DR: A significant increase in the risk of cutaneous malignant melanoma was also associated with number of weeks spent on holiday at the beach not only as an adult, but also as a child.

TL;DR: PTHRP is implicated as the humoral factor responsible for hypercalcaemia associated with breast cancer and tumour positivity may be a useful predictor of which women will develop bone metastases.

TL;DR: Amplification of c-myc, HER2/neu and int-2/bcl-1 genes in a series of 1052 collected human breast tumours showed a large fluctuation, which could be attributed to the study of relatively small series of tumours, to selection of subgroups of patients, or, especially in retrospective studies, to Selection of tumour material from the tumour-bank.

TL;DR: The addition of IFN-alpha is beneficial for patients with malignant carcinoid tumours that progress and/or who do not respond to octreotide.

TL;DR: The data suggest that in comparison to ondansetron, granisetron is a more potent, longer acting and pharmacologically "cleaner" compound with a more conventional dose-response profile.

TL;DR: Results show that pp60c-src may be activated in human lung carcinomas of different histopathological types.

TL;DR: It is suggested that sequential rather than simultaneous administration of topoisomerase I and II inhibitors in future cancer chemotherapy schedules will enhance cytotoxicity over single-agent administration.

TL;DR: Several systems of deregulation in EGFr production may exist and could be located at translational and/or post-translational levels.

TL;DR: MCF-7 and HT-29 cell lines were selected as a reliable model to examine the possible parameters affecting the sensitivity of tumour cells to photodynamic therapy using a dye-laser at 630 nm and showed a maximal cytotoxicity 48 h after photoirradiation.

TL;DR: This paper describes the use of the triphenylethylene tamoxifen, and a new chlorinated analogue, toremifene, in 20 patients with progressive desmoid disease and emphasises the significance of stroma within breast (and other) tumours, in particular how the stroma may regulate the response to these drugs regardless of receptor status.

TL;DR: The interactions of tumour- and treatment-related factors is complex, but adequacy of surgical excision, quality of radiation therapy technique, and use of systemic therapy all appear to contribute to risk reduction.

TL;DR: It is concluded that a wide resection in healthy tissue is indispensable for malignant and borderline phyllodes tumours, while where benign phyllode tumour is encountered unexpectedly, even if a limited resection was performed, a wait-and-see policy is justified.

TL;DR: The results show that effective local treatment can prevent distant dissemination in some patients and contradict the contention that node-positive breast cancer invariably is a systemic disease already at primary diagnosis.

TL;DR: Primary chemotherapy enhanced the possibility of breast conservation in up to 83% of the cases in a series in which most would have been otherwise subjected to a MRM because of tumour size.

TL;DR: The results indicate that K-ras mutation provides a stable tumour marker throughout the natural history of colorectal cancer.