Journal ArticleDOI
Differential expression of angiotensin receptors in human cutaneous wound healing.
Reads0
Chats0
TLDR
This data indicates that downregulation of AT2 receptors in human skin during tissue repair and remodelling in various noncutaneous human tissues is a major cause of apoptosis in animals.Abstract:
Summary
Background Angiotensin AT1 and AT2 receptors are expressed in human skin. Furthermore, AT2 receptors have been reported to be upregulated during tissue repair and remodelling in various noncutaneous human tissues.
Objectives Detection of alterations in angiotensin II receptor expression during wound healing in human skin.
Methods Three models were employed. (i) Primary human keratinocytes were razor scraped in culture flasks and alterations in the expression of angiotensin receptor mRNA determined by semiquantitative reverse transcription–polymerase chain reaction for 1–12 h thereafter. (ii) Early wound healing (48 h after cutting) was studied in punch biopsies from human skin ex vivo by means of immunohistochemical staining using polyclonal antibodies against the AT1 or AT2 receptor. (iii) In vivo wound healing was studied in sections of human cutaneous scars by immunohistochemistry to determine receptor expression early (2 days) and late (2 weeks−3 months) after surgery.
Results In all experimental settings, an upregulation of both receptor subtypes was noticed after wounding. Immunohistochemically stained skin sections showed a stronger expression of AT2 than of AT1 receptors within the area of scarring. Enhanced receptor expression was detectable as early as 24 h after injury and lasted for up to 3 months.
Conclusions From these data, we conclude that angiotensin AT1 and AT2 receptors are upregulated in human cutaneous wounds, giving further support to the concept that angiotensin II plays a role even at an early stage during cutaneous wound healing.read more
Citations
More filters
Journal ArticleDOI
Pathogenesis and Treatment of Impaired Wound Healing in Diabetes Mellitus: New Insights
TL;DR: An outlook of the pathophysiology in diabetic wound healing is provided and the established and adjunctive treatment strategies, as well as the future therapeutic options for the treatment of DFUs are summarized.
Journal ArticleDOI
The AT2 receptor--a matter of love and hate.
TL;DR: The present review summarizes the current knowledge of AT2 receptor distribution, signaling and function with an emphasis on growth/anti-growth, differentiation and the regeneration of neuronal tissue.
Journal ArticleDOI
Angiotensin II and the vascular phenotype in hypertension.
TL;DR: Recent developments and new research trends related to Ang II and the RAS and involvement in the hypertensive vascular phenotype are focused on.
Journal ArticleDOI
Review article: the pathophysiological roles of the renin–angiotensin system in the gastrointestinal tract
Mayur Garg,Peter W Angus,Peter W Angus,Louise M Burrell,Chandana B Herath,Peter R. Gibson,John S Lubel,John S Lubel +7 more
TL;DR: The renin‐angiotensin system (RAS) is a homeostatic pathway widely known to regulate cardiovascular and renal physiology; however, little is known about its influence in gastrointestinal tissues.
Journal ArticleDOI
Angiotensin Type 2 Receptor in Resistance Arteries of Type 2 Diabetic Hypertensive Patients
TL;DR: AT2Rs are upregulated and contribute to angiotensin II–induced vasodilation in resistance arteries of hypertensive diabetic patients treated with angiotENSin type 1 receptor blockers and may mediate, in part, vascular actions of these drugs in high cardiovascular risk patients.
References
More filters
Journal Article
International Union of Pharmacology. XXIII. The Angiotensin II Receptors
TL;DR: Although AT(1) receptors mediate most of the known actions of Ang II, the AT(2) receptor contributes to the regulation of blood pressure and renal function and the development of specific nonpeptide receptor antagonists has led to major advances in the physiology, pharmacology, and therapy of the renin-angiotensin system.
Journal ArticleDOI
The angiotensin AT2-receptor mediates inhibition of cell proliferation in coronary endothelial cells.
TL;DR: The results show that the growth modulating actions of ANG II depend on the type of angiotensin receptor present on a given cell, and in coronary endothelial cells, the antiproliferative actions of the AT2-receptor offset the growth promoting effects mediated by the AT1- receptor.
Journal ArticleDOI
Mechanisms of Tubulointerstitial Fibrosis
Michael Zeisberg,Eric G. Neilson +1 more
TL;DR: In combination with traditional angiotensin converting enzyme inhibitors, newly identified cytokines may eventually form the basis for new therapeutic strategies aimed at inhibiting the progression of renal disease.
Journal ArticleDOI
The angiotensin II type 2 (AT2) receptor antagonizes the growth effects of the AT1 receptor: gain-of-function study using gene transfer
Masatoshi Nakajima,Howard G. Hutchinson,Masahiko Fujinaga,Wataru Hayashida,Ryuichi Morishita,Lunan Zhang,Masatsugu Horiuchi,Richard E. Pratt,Victor J. Dzau +8 more
TL;DR: Results suggest that the AT2 receptor exerts an antiproliferative effect, counteracting the growth action of AT1 receptor.
Journal ArticleDOI
Inflammation and angiotensin II.
TL;DR: Recent data support the hypothesis that RAS is key mediator of inflammation, and further understanding of the role of the RAS in this process may provide important opportunities for clinical research and treatment of inflammatory diseases.
Related Papers (5)
Angiotensin AT1/AT2 receptors: regulation, signalling and function.
Elena Kaschina,Thomas Unger +1 more