Showing papers in "The International Journal of Biochemistry & Cell Biology in 2003"

TL;DR: Recent data support the hypothesis that RAS is key mediator of inflammation, and further understanding of the role of the RAS in this process may provide important opportunities for clinical research and treatment of inflammatory diseases.

TL;DR: Immunohistochemical and neuropharmacological studies suggest that angiotensinergic neural pathways and angiotENSin peptides are important in neural function and may have important homeostatic roles, particularly related to cardiovascular function, osmoregulation and thermoregulating.

TL;DR: Skeletal muscle satellite cells are quiescent mononucleated myogenic cells, located between the sarcolemma and basement membrane of terminally-differentiated muscle fibres that act as a reserve population of cells, able to proliferate in response to injury and give rise to regenerated muscle and to more satellite cells.

TL;DR: The beneficial effects of ACE-inhibition and angiotensin-receptor blockade on the development of type 2 diabetes in large clinical trials suggest a pathophysiological role of the adipose-tissue renin-angiotens in system in the metabolic syndrome.

TL;DR: Once formed, aggresomes can impair the function of the proteasome system, which may promote apoptosis, and under favorable conditions they can be cleared, probably by autophagy.

TL;DR: Recombinantly expressed protein initiates and promotes chondrogenesis and to a limited extent osteogenesis in vitro and in vivo, which makes this polypeptide a potential therapeutic agent in the regeneration of skeletal tissues.

TL;DR: These cells express molecular markers similar to those of skeletal, cardiac and smooth muscle cells (SMCs) and in particular, many ICs express smooth muscle (SM) alpha-actin, a marker of myofibroblasts, which may allude to their role in valve function.

TL;DR: By regulating osteoclast differentiation and activity in response to systemic influences, osteoblasts not only play a central role in regulation of skeletal architecture, but also in calcium homeostasis.

TL;DR: Mouse knockout experiments, and comparative work with invertebrate homologues, suggest that the two domains of angiotensin converting enzyme have clearly distinct roles.

TL;DR: The cross-talk of the actin cytoskeleton with the microtubule network is discussed and the potential mechanisms that control the differential behavior of focal adhesions sites during cell migration are discussed.

TL;DR: Interactions involving GPIb-IX-V are central to vascular processes of thrombosis and inflammation, and the receptor is under intense scrutiny as a potential therapeutic target.

TL;DR: It is conceivable that single nucleotide polymorphisms in the regulatory regions of genes in these proteolytic cascades, which alter their expression, could contribute to some of the age-related changes seen in AD.

TL;DR: Novel therapeutic strategies to prevent or reverse goblet cell hyperplasia include inhibitors of EGF receptor tyrosine kinase and CLCA, of which viable pharmaceutical molecules are now available for clinical trial in hypersecretory conditions of the airways.

TL;DR: CHIP is an ideal molecule acting as a protein quality-control ubiquitin ligase that selectively leads abnormal proteins recognized by molecular chaperones to degradation by the proteasome, accumulating evidence from in vitro studies indicates.

TL;DR: The present results lend further support to the concept that the ubiquitin-proteasome pathway plays an important role in sepsis-induced muscle proteolysis and suggest that multiple ubiquitIn ligases may participate in the development of muscle wasting during sepsi.

TL;DR: It is concluded that the functional classification of serpins relies on their protein structure and not on sequence similarity, andVertebrate serpins can be conveniently classified into six sub-groups.

TL;DR: Recent findings provide strong support for the concept that ubiquitination is regulated by both specific pathways of ubiquitinations and deubiquitination, as well as to modify functions of some target proteins.

TL;DR: Insight into mechanisms regulating migration of neutrophils could potentially lead to novel therapeutic strategies for counteracting chronic activation of Neutrophils which leads to tissue damage.

TL;DR: The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is the commonest form of normovolaemic or dilutional hyponatraemia and the mainstay of therapy remains fluid restriction.

TL;DR: This review summarizes the current knowledge of the structural features of the 20S proteasome holoenzyme, a 2.5MDa molecular machine built from more than 31 different subunits.

TL;DR: The elucidation of the structural details of Eph-ephrin recognition and binding should yield insight into the future development of novel therapeutic agents targeting cardiovascular function, nerve regeneration, and cancer.

TL;DR: There is now compelling evidences that they are important players in innate and acquired immunity, wound healing, fibrosis, tumors and autoimmune diseases, and this review will discuss current advances in these fields.

TL;DR: A local renin-angiotensin system (RAS) may be suggested by evidence of gene expression of RAS components within the tissue as well as physiological responsiveness of this gene expression, via its relation with pharmacological intervention and genetic studies.

TL;DR: This chapter dwells on the theme of constancy of H(+) of the blood and of the other internal environments, and the mechanisms of membrane depolarization of the chemoreceptor cells because this is one mechanism on which the responses depend.

TL;DR: Both angiotensin and kinin peptides are metabolised by many different peptidases that are important determinants of the activities of the RAS and KKS, and several of which participate in both systems.

TL;DR: An overview of recent work on ternary complex factors is provided, addressing their expression and molecular structure, as well as how selective interactions with members of other protein families serve to up-1 regulate or restrict their activity.

TL;DR: The physiological and pathological actions of AngII in adults are mediated largely via the AngII type 1 receptor (AT1R), a heterotrimeric G-protein-coupled receptor (GPCR) that binds to receptor tyrosine kinases and plays critical roles in AngII-stimulated cell signal events.

TL;DR: HGC contained about 2-fold increased amounts of GAGs in comparison to HNG, and the accumulation of core proteins of versican and decorin in HGC was also associated with many post-translational modifications, referring to the number, size, degree and patterns of sulphation and epimerization of CS/DS chains.

TL;DR: This review critically reviews the current evidence for hydrolysis-independent bradykinin potentiation by ACE inhibitors, evaluating not only the many studies that have been performed with ACE-resistant bradykinsin analogues, but also paying attention to angiotensin-(1-7), a metabolite of both angioten I and II, that could act as an endogenous ACE inhibitor.

TL;DR: Discovery of the Apg12 system has facilitated the understanding of the molecular mechanism of autophagosome formation and identified two enzymes catalyzing this conjugation reaction.