Journal ArticleDOI
Differential Production of Reactive Oxygen Species by Subsets of Human Spermatozoa
TLDR
The results of this study indicate that there is significant cell-to-cell variation in ROS production in subsets of spermatozoa at different stages of maturation and that oxidative damage of mature spermatoza by ROS-producing immature spermatozosa during sperm migration from the seminiferous tubules to the epididymis may be an important cause of male infertility.About:
This article is published in Fertility and Sterility.The article was published on 2000-09-01. It has received 196 citations till now.read more
Citations
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Journal ArticleDOI
Role of reactive oxygen species in the pathophysiology of human reproduction
TL;DR: High levels of ROS are detrimental to the fertility potential both in natural and assisted conception states.
Journal ArticleDOI
Oxidative stress and male infertility: from research bench to clinical practice.
Ramadan A Saleh,Ashok Agarwal +1 more
TL;DR: Extensive research in the Cleveland Clinic indicates that the seminal oxidative stress test has diagnostic and prognostic capabilities beyond those of conventional tests of sperm quality or functions and may be of particular importance to the future management of male infertility.
Journal ArticleDOI
Significance of mitochondrial reactive oxygen species in the generation of oxidative stress in spermatozoa.
TL;DR: The sperm mitochondria make a significant contribution to the oxidative stress experienced by defective human spermatozoa, as well as the subcellular origins of this activity are unclear.
Journal ArticleDOI
Role of antioxidants in treatment of male infertility: an overview of the literature
TL;DR: It was found that although many clinical trials have demonstrated the beneficial effects of antioxidants in selected cases of male infertility, some studies failed to demonstrate the same benefit, and conclusive evidence on the benefit of antioxidants as a treatment modality for patients with male infertility is still needed.
Journal ArticleDOI
The role of sperm oxidative stress in male infertility and the significance of oral antioxidant therapy
TL;DR: Adequately powered, placebo-controlled comprehensive clinical trials are now required to establish a clear role for antioxidants in the prevention of oxidative stress in the male germ line, such that the clinical utility of this form of therapy becomes established once and for all.
References
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Journal ArticleDOI
Role of reactive oxygen species in the pathophysiology of human reproduction
TL;DR: High levels of ROS are detrimental to the fertility potential both in natural and assisted conception states.
Journal ArticleDOI
Sperm morphologic features as a prognostic factor in in vitro fertilization.
Thinus F. Kruger,Roelof Menkveld,F. S. H. Stander,Carl Lombard,Jacobus P. Van der Merwe,Johannes A. van Zyl,Karen Smith +6 more
TL;DR: In this article, the authors conducted a prospective study in women with bilateral tubal damage to determine whether there is a prognostic value in the percentage normal sperm morphologic features in a human in vitro fertilization (IVF) program.
Journal ArticleDOI
Cellular basis of defective sperm function and its association with the genesis of reactive oxygen species by human spermatozoa.
TL;DR: Studies with scavengers of reactive oxygen species revealed that, while reagents directed against singlet oxygen and the hydroxyl radical were without effect, cytochrome C reduced the response to A23187 by about 50%, suggesting that the superoxide anion radical is a major product of the activated human spermatozoon.
Journal ArticleDOI
Spontaneous lipid peroxidation and production of hydrogen peroxide and superoxide in human spermatozoa. Superoxide dismutase as major enzyme protectant against oxygen toxicity.
TL;DR: The results suggest that superoxide dismutase plays the major role in protecting human spermatozoa against lipid peroxidation, and the superoxide Dismutase activity of a fresh sperm sample appears to be a good predictor of the lifetime (up to the complete loss of motility) of that particular sample, and so may prove useful in semen analysis.
Journal ArticleDOI
Role of reactive oxygen species in male infertility.
Rakesh Sharma,Ashok Agarwal +1 more
TL;DR: From the current data it appears that no single adjuvant will be able to enhance the fertilizing capacity of sperm in infertile men, and a combination of the possible strategies that are not toxic at the dosage used would be a feasible approach.
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