Open AccessJournal Article
Diffuse alveolar damage--the role of oxygen, shock, and related factors. A review.
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Acute respiratory distress syndrome: the Berlin Definition.
Ards Definition Task Force,V. Marco Ranieri,Gordon D. Rubenfeld,B. Taylor Thompson,Niall D. Ferguson,Ellen Caldwell,Eddy Fan,Luigi Camporota,Luigi Camporota,Arthur S. Slutsky +9 more
TL;DR: The updated and revised Berlin Definition for ARDS addresses a number of the limitations of the AECC definition and may serve as a model to create more accurate, evidence-based, critical illness syndrome definitions and to better inform clinical care, research, and health services planning.
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Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19.
Maximilian Ackermann,Stijn E. Verleden,Mark Kuehnel,Axel Haverich,Tobias Welte,Florian Laenger,Arno Vanstapel,Christopher Werlein,Helge Stark,Alexandar Tzankov,William W. Li,Vincent W. Li,Steven J. Mentzer,Danny Jonigk +13 more
TL;DR: In this small series, vascular angiogenesis distinguished the pulmonary pathobiology of Covid-19 from that of equally severe influenza virus infection.
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An Official American Thoracic Society Workshop Report: Features and Measurements of Experimental Acute Lung Injury in Animals
Gustavo Matute-Bello,Gregory P. Downey,Bethany B. Moore,Steve D. Groshong,Michael A. Matthay,Arthur S. Slutsky,Wolfgang M. Kuebler +6 more
TL;DR: This list of features and measurements of ALI is intended as a guide for investigators, and ultimately investigators should choose the particular measurements that best suit the experimental questions being addressed as well as take into consideration any unique aspects of the experimental design.
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The Berlin definition of ARDS: An expanded rationale, justification, and supplementary material
Niall D. Ferguson,Eddy Fan,Luigi Camporota,Massimo Antonelli,Antonio Anzueto,Richard Beale,Laurent Brochard,Roy G. Brower,Andrés Esteban,Luciano Gattinoni,Andrew Rhodes,Arthur S. Slutsky,Jean Louis Vincent,Gordon D. Rubenfeld,B. Taylor Thompson,V. Marco Ranieri +15 more
TL;DR: This panel addressed some of the limitations of the prior ARDS definition by incorporating current data, physiologic concepts, and clinical trials results to develop the Berlin definition, which should facilitate case recognition and better match treatment options to severity in both research trials and clinical practice.
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Association of hemoglobin A1c with cardiovascular disease and mortality in adults: the European prospective investigation into cancer in Norfolk.
TL;DR: The relation between hemoglobin A1c concentrations and fatal and nonfatal coronary heart disease, cardiovascular disease events, and all-cause mortality in men and women after an average of 6 years of follow-up is reported.
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Journal ArticleDOI
Acute respiratory distress in adults.
TL;DR: Positive end-expiratory pressure was most helpful in combating atelectasis and hypoxaemia and Corticosteroids appeared to have value in the treatment of patients with fat-embolism and possibly viral pneumonia.
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Pulmonary disease following respirator therapy of hyaline-membrane disease. Bronchopulmonary dysplasia.
TL;DR: Intensive therapy may modify the acute syndrome so as to permit the development of a previously unrecorded abnormality of hyaline-membrane disease.
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The Adult Respiratory Distress Syndrome: Clinical Features, Factors Influencing Prognosis and Principles of Management
TL;DR: The adult respiratory distress syndrome (ARDS) is an important and common medical emergency and is likely to occur in all hospitals dealing in respiratory care as mentioned in this paper, which occurs from a variety of diffuse pulmonary injuries which are either direct or indirect attacks on the lung parenchyma.
Journal Article
The type 2 cell as progenitor of alveolar epithelial regeneration. A cytodynamic study in mice after exposure to oxygen.
I Y Adamson,Drummond H. Bowden +1 more
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Pulmonary lesions associated with oxygen therapy and artificial ventilation.
TL;DR: Patients requiring mechanical artificial ventilation have increasing reduction in pulmonary compliance and vital capacity, with consequent hypoxia, are difficult to wean from the ventilator and often die of pulmonary insufficiency.