C
Christopher Werlein
Researcher at Hannover Medical School
Publications - 52
Citations - 4520
Christopher Werlein is an academic researcher from Hannover Medical School. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 4, co-authored 24 publications receiving 2584 citations. Previous affiliations of Christopher Werlein include University of Mainz & Hochschule Hannover.
Papers
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Journal ArticleDOI
Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19.
Maximilian Ackermann,Stijn E. Verleden,Mark Kuehnel,Axel Haverich,Tobias Welte,Florian Laenger,Arno Vanstapel,Christopher Werlein,Helge Stark,Alexandar Tzankov,William W. Li,Vincent W. Li,Steven J. Mentzer,Danny Jonigk +13 more
TL;DR: In this small series, vascular angiogenesis distinguished the pulmonary pathobiology of Covid-19 from that of equally severe influenza virus infection.
Journal ArticleDOI
Imaging intact human organs with local resolution of cellular structures using hierarchical phase-contrast tomography.
Claire Walsh,Paul Tafforeau,Willi L. Wagner,Daniyal J. Jafree,Alexandre Bellier,Christopher Werlein,Mark Kühnel,Elodie Boller,Simon Walker-Samuel,J. L. Robertus,David A. Long,J. Jacob,Sebastian Marussi,E. Brown,Natalie A. Holroyd,Danny Jonigk,Maximilian Ackermann,Peter D. Lee +17 more
TL;DR: In this article, a hierarchical phase-contrast tomography (HiP-CT) was developed to image intact human organs from the organ to the cellular scale in 3D.
Journal ArticleDOI
Multisystemic Cellular Tropism of SARS-CoV-2 in Autopsies of COVID-19 Patients.
Dickson W.L. Wong,Barbara M. Klinkhammer,Sonja Djudjaj,Sophia Villwock,M. Cherelle Timm,Eva Miriam Buhl,Sophie Wucherpfennig,Claudio Cacchi,Till Braunschweig,Ruth Knüchel-Clarke,Danny Jonigk,Christopher Werlein,Roman D. Bülow,Edgar Dahl,Saskia von Stillfried,Peter Boor +15 more
TL;DR: In this paper, the authors comprehensively analyzed 25 different formalin-fixed paraffin-embedded (FFPE) tissues/organs from autopsies of fatal COVID-19 cases (n = 8), using histopathological assessment, detection of SARS-CoV-2 RNA using polymerase chain reaction and RNA in situ hybridization, viral protein using immunohistochemistry, and virus particles using transmission electron microscopy.
Journal ArticleDOI
3D virtual pathohistology of lung tissue from Covid-19 patients based on phase contrast X-ray tomography.
Marina Eckermann,Jasper Frohn,Marius Reichardt,Markus Osterhoff,Michael Sprung,Fabian Westermeier,Alexandar Tzankov,Christopher Werlein,Mark Kühnel,Danny Jonigk,Tim Salditt +10 more
TL;DR: This first proof-of-concept study proposes multi-scale phase contrast x-ray tomography as a tool to unravel the pathophysiology of Covid-19, extending conventional histology by a third dimension and allowing for full quantification of tissue remodeling.
Journal ArticleDOI
First report from the German COVID-19 autopsy registry
Saskia von Stillfried,Roman D. Bülow,R. Röhrig,P. K. Ilja Boor,J F Böcker,J. B. Schmidt,Pauline Tholen,Raphael W. Majeed,Jan Wienströer,Joachim Weis,Juliane Bremer,Ruth Knüchel,Anna Breitbach,Claudio Cacchi,Benita Freeborn,Sophie Wucherpfennig,Oliver Spring,Georg Braun,Christoph Römmele,Bruno Märkl,R Claus,Christine Dhillon,Tina Schaller,Éva Sipos,Klaus Hirschbühl,M. Wittmann,Elisabeth Kling,Thomas Kröncke,Frank L. Heppner,Jenny Meinhardt,Helena Radbruch,S. Streit,David Horst,Sefer Elezkurtaj,Alexander Quaas,Heike Göbel,Torsten Hansen,Ulf Titze,Johan M. Lorenzen,Thomas Reuter,Jaroslaw Woloszyn,Gustavo B. Baretton,Julia Hilsenbeck,Matthias Meinhardt,Jessica Pablik,Linna Sommer,Olaf Holotiuk,Meike Meinel,Nina Sophia Mahlke,Irene Esposito,Graziano Domenico Luigi Crudele,Maximilian Seidl,Kerstin Amann,Roland Coras,Arndt Hartmann,Philip Eichhorn,Florian Haller,Fabienne Lange,Kurt Schmid,Marc Ingenwerth,Josefine Rawitzer,Dirk Theegarten,Christoph G Birngruber,Peter Wild,Elise Gradhand,Kevin John. Smith,Martin Werner,Oliver S. Schilling,Till Acker,Stefan Gattenlöhner,Christine Stadelmann,Imke Metz,Jonas Franz,Lidia Stork,Carolina Thomas,Sabrina Zechel,Philip Ströbel,Claudia Wickenhauser,Christine Fathke,Anja Harder,Benjamin Ondruschka,E. Dietz,Carolin Edler,Antonia Fitzek,D. Fröb,Axel Heinemann,Fabian Heinrich,Anke Klein,Inga Kniep,Larissa Lohner,Dustin Möbius,Klaus Püschel,Julia Schädler,Ann Sophie Schröder,Jan-Peter Sperhake,Martin Aepfelbacher,Nicole Fischer,Marc Lütgehetmann,Susanne Pfefferle,Markus Glatzel,Susanne Krasemann,Jakob Matschke,Danny Jonigk,Christopher Werlein,Peter Schirmacher,Lisa Domke,Laura Hartmann,Isabel Klein,Constantin Schwab,Christoph Röcken,Johannes Friemann,Dorothea Langer,Wilfried Roth,Stephanie Strobl,Martina Rudelius,Konrad Stock,Wilko Weichert,Claire Delbridge,Atsuko Kasajima,Peer-Hendrik Kuhn,Julia Slotta-Huspenina,Gregor Weirich,Peter Barth,Eva Wardelmann,Katja Evert,Andreas Büttner,Johannes Manhart,Stefan Nigbur,Iris Bittmann,Falko Fend,Hans Bösmüller,Massimo Granai,Karin Klingel,Verena Warm,Konrad Steinestel,Vincent G. Umathum,Andreas Rosenwald,Florian Kurz,Niklas Vogt +138 more
TL;DR: The German COVID-19 Autopsy Registry (DeRegCOVID) was launched in April 2020 as mentioned in this paper , which included N=1129 autopsy cases, with 69271 single data points including information on 18674 available biospecimens gathered from 29 German sites.