Dioscorea Plants: A Genus Rich in Vital Nutra-pharmaceuticals-A Review.
Bahare Salehi,Bilge Sener,Mehtap Kilic,Javad Sharifi-Rad,Rabia Naz,Zubaida Yousaf,Fhatuwani N. Mudau,Patrick Valere Tsouh Fokou,Shahira M. Ezzat,Mahitab H. El Bishbishy,Yasaman Taheri,Giuseppe Lucariello,Alessandra Durazzo,Massimo Lucarini,Hafiz Ansar Rasul Suleria,Antonello Santini +15 more
TLDR
Dioscorea is a potential source of bioactive substances of interest in the prevention/treatment of several diseases, and thus represents a great challenge in developing countries, however, ethnomedicinal potential should be validated and further researches on pharmacological properties and phytochemical composition should be carried out.Abstract:
Dioscorea species, known as "Yams," belong to family Dioscoreaceae. This genus consists of more than 600 species distributed from Africa, Asia, the Caribbean's South America, and the South Pacific islands. Their organoleptic properties make them the most widely used carbohydrate food and dietary supplements. The underground and/or aerial tubers represent valuable sources of proteins, fats, and vitamins for millions of people in West Africa. This review gives a shot of secondary metabolites of Dioscorea plants, including steroids, clerodane diterpenes, quinones, cyanidins, phenolics, diarylheptanoids, and nitrogen-containing compounds. This review collected the evidence on biological properties of description Dioscorea, including in-vitro and in-vivo studies. Dioscorea species contain promising bioactive molecules i.e. diosgenin that support their different biological properties, including antioxidant, hypoglycaemic, hypolipidemic, anti- antimicrobial, inflammatory, antiproliferative, androgenic, estrogenic, and contraceptive drugs. Indeed, besides its nutrient values, Dioscorea is a potential source of bioactive substances of interest in the prevention/treatment of several diseases, and thus represents a great challenge in developing countries. However, ethnomedicinal potential should be validated and further researches on pharmacological properties and phytochemical composition should be carried out. Particularly, doing some studies to convert the preclinical results to clinical efficacy should be guaranteed. Dioscorea, Food plant, Traditional use, Phytochemistry, Pharmacological activities.read more
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Recent developments of gallic acid derivatives and their hybrids in medicinal chemistry: A review
TL;DR: This review is an update on the latest development of the chemistry and the medicinal impacts of pharmacophores containing gallic acids, and presents and discusses fused gallic acid derivatives and hybrid molecules containing different bioactive moieties in the presence of gallic Acid.
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Effects of phytochemicals from plant-based functional foods on hyperlipidemia and their underpinning mechanisms
TL;DR: The development of plant-based functional foods with potent hypolipidemic properties is a promising approach for the management of obesity, diabetic dyslipidemia, and cardiovascular disease.
Journal ArticleDOI
Resveratrol, curcumin, paclitaxel and miRNAs mediated regulation of PI3K/Akt/mTOR pathway: go four better to treat bladder cancer.
Khushbukhat Khan,Cristina Quispe,Zeeshan Javed,Muhammad Javed Iqbal,Haleema Sadia,Shahid Raza,Asma Irshad,Bahare Salehi,Željko Reiner,Javad Sharifi-Rad +9 more
TL;DR: The aim of this review is to discuss the interplay between PI3K/Akt/mTOR, miRNAs, and natural compounds and emphasize the importance of mi RNAs as biomarkers and resveratrol, curcumin and paclitaxel as a possible therapeutic approach against bladder cancer.
Journal ArticleDOI
Cytotoxic phenanthrenes and phenolic constituents from the tubers of Dioscorea persimilis
Nguyen Thi Thanh Ngan,Nguyen Huy Hoang,Nguyen Thu Hien,Nguyen Ngoc Lan,Nguyen Thi Kim Lien,Tran Hong Quang,Nguyen Xuan Cuong,Nguyen Hoai Nam,Chau Van Minh +8 more
TL;DR: In this paper, the authors described the isolation of 11 secondary metabolites from Dioscorea persimilis, including three new phenanthrenes namely diospersimilosides A (1) and B (2) and diosbiphenanthrene (3), and eight known phenolic compounds: 2,4,6,7-tetrahydroxy-9,10-dihydrophenanthrone (4), aerosin (5), gastrodin (6), 2-phenylethyl-β-d -glucop
Journal ArticleDOI
Juglans mandshurica Maxim.: A Review of Its Traditional Usages, Phytochemical Constituents, and Pharmacological Properties.
Fei Luan,Ziyan Wang,Yan Yang,Yafei Ji,Haizhen Lv,Keqing Han,Daoheng Liu,Xiaofei Shang,Xirui He,Nan Zeng +9 more
TL;DR: The present review will provide some specific useful suggestions guide to further investigations and applications of this plant in the preparation of medicines and functional foods.
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