Journal ArticleDOI
Direct effects of progesterone and antiprogesterone on human sperm hyperactivated motility and acrosome reaction
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TLDR
In this article, the effects of progesterone and its antagonist RU486 (mifepristone) on sperm hyperactivation (HA) and acrosome reaction were investigated in a study at a tertiary care center.About:
This article is published in Fertility and Sterility.The article was published on 1992-12-01. It has received 140 citations till now. The article focuses on the topics: Acrosome reaction & Hyperactivation.read more
Citations
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Journal ArticleDOI
Progesterone activates the principal Ca2+ channel of human sperm.
TL;DR: It is found that nanomolar concentrations of progesterone dramatically potentiate CatSper, a pH-dependent Ca2+ channel of the sperm flagellum, which represents a promising target for the development of a new class of non-hormonal contraceptives.
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Capacitation as a regulatory event that primes spermatozoa for the acrosome reaction and fertilization.
TL;DR: Capacitation is defined as the series of transformations that spermatozoa normally undergo during their migration through the female genital tract, in order to reach and bind to the zona pellucida, undergo the acrosome reaction, and fertilize the egg as discussed by the authors.
Journal ArticleDOI
Nongenomic actions of steroid hormones in reproductive tissues.
TL;DR: Cross-Talk between the Nongenomic and Genomic Responses of Cells to Steroids VII shows that the GABAA-like receptor/Cl− channel and the PTK system are important sources of uncertainty in the mechanism behind the effects of estrogens.
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Characteristics of membrane progestin receptor alpha (mPRα) and progesterone membrane receptor component 1 (PGMRC1) and their roles in mediating rapid progestin actions
TL;DR: Many aspects of progestin signaling through these two families of novel membrane proteins remain unresolved, but evidence has been obtained that PGMRC1 mediates the antiapoptotic affects of progesterone in rat granulosa cells.
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A critical review of the physiological importance and analysis of sperm movement in mammals
TL;DR: A critical review of a number of aspects of hyperactivated motility, including its identification and potential role(s) in mammalian fertilization, is presented.
References
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Journal ArticleDOI
Two simple methods for detecting acrosome‐reacted human sperm
TL;DR: Two methods for detecting acrosome reactions of human sperm at the light microscopic level are described, rapid, give similar results, and detect an increase in acrosomes reactions following exposure to the ionophore A23187.
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Contragestion and other clinical applications of RU 486, an antiprogesterone at the receptor
TL;DR: RU 486, a steroid with high affinity for the progesterone receptor, is the first available active antiprogesterone, and it has been used successfully as a medical alternative for early pregnancy interruption.
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Progesterone and 17 alpha-hydroxyprogesterone. Novel stimulators of calcium influx in human sperm.
TL;DR: The effects of these progestins to increase [Ca2+]i, by activating a receptor-operated calcium channel, is the first report of such an activity in sperm.
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Steroid induced exocytosis: the human sperm acrosome reaction.
TL;DR: It is argued that progesterone is present at the site of fertilization of placental mammals in concentrations sufficient for activity, and hence provides a mechanism of inducing the acrosome reaction, an exocytotic event, in vivo.
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Phosphatidylinositol 4,5-bisphosphate hydrolysis in human sperm stimulated with follicular fluid or progesterone is dependent upon Ca2+ influx
Paul Thomas,Stanley Meizel +1 more
TL;DR: It is reported here that both a Sephadex G-75 column fraction, derived from follicular fluid, and progesterone stimulate rapid hydrolysis of PtdIns(4,5)P2 and PTDIns4P in human sperm and that progester one stimulates a rapid influx of Ca2+ inhuman sperm.