Journal ArticleDOI
Direct evidence that polysorbate-80-coated poly(butylcyanoacrylate) nanoparticles deliver drugs to the CNS via specific mechanisms requiring prior binding of drug to the nanoparticles.
Jörg Kreuter,Peter Ramge,Petrov Ve,Stefan Hamm,Svetlana Gelperina,Britta Engelhardt,Renad N. Alyautdin,Hagen von Briesen,David J. Begley +8 more
TLDR
There is little in vivo or in vitro evidence to suggest that a generalized toxic effect on the BBB is the primary mechanism for drug delivery to the brain, and the fact that dalargin has to be preadsorbed onto nanoparticles before it is effective in inducing antinociception suggests specific mechanisms of Delivery to the CNS.Abstract:
Purpose. It has recently been suggested that the poly(butylcyanoacrylate) (PBCA) nanoparticle drug delivery system has a generalized toxic effect on the blood-brain barrier (BBB) (8) and that this effect forms the basis of an apparent enhanced drug delivery to the brain. The purpose of this study is to explore more fully the mechanism by which PBCA nanoparticles can deliver drugs to the brain.read more
Citations
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Drug delivery and nanoparticles:applications and hazards
Wim H. de Jong,Paul J A Borm +1 more
TL;DR: An overview on some of the currently used systems for drug delivery, varying from biological substances like albumin, gelatine and phospholipids for liposomes, and more substances of a chemical nature like various polymers and solid metal containing nanoparticles is provided.
Journal ArticleDOI
Nanoparticle-based targeted drug delivery
TL;DR: This article presents an overview of nanotechnology for the biologist and discusses the attributes of the novel XPclad((c)) nanoparticle formulation that has shown efficacy in treating solid tumors, single dose vaccination, and oral delivery of therapeutic proteins.
Journal ArticleDOI
Applications of nanoparticles in biology and medicine
TL;DR: This brief review tries to summarise the most recent developments in the field of applied nanomaterials, in particular their application in biology and medicine, and discusses their commercialisation prospects.
Journal ArticleDOI
Nanomedicine: current status and future prospects
TL;DR: Rational approaches in design and surface engineering of nanoscale vehicles and entities for site‐specific drug delivery and medical imaging after parenteral administration are highlighted.
Journal ArticleDOI
Engineered Nanoparticles for Drug Delivery in Cancer Therapy
TL;DR: It is anticipated that precisely engineered nanoparticles will emerge as the next-generation platform for cancer therapy and many other biomedical applications.
References
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Journal Article
Growth and cultivation of dissociated neurons and glial cells from embryonic chick, rat and human brain in flask cultures
Booher J,Sensenbrenner M +1 more
Journal ArticleDOI
An easier, reproducible, and mass-production method to study the blood-brain barrier in vitro.
Marie-Pierre Dehouck,Stéphane Méresse,Pierre Delorme,Jean-Charles Fruchart,Roméo Cecchelli,Roméo Cecchelli +5 more
TL;DR: This work has developed a process ofoculture that closely mimics the “in vivo” situation by culturing brain capillary endothelial cells on one side of a filter and astrocytes on the other, and which is impermeable to inulin and sucrose but allows the transport of leucine.
Journal ArticleDOI
Passage of peptides through the blood-brain barrier with colloidal polymer particles (nanoparticles)
TL;DR: Fluorescent and electron microscopic studies indicated that the passage of the particle-bound drug occurred by phagocytic uptake of the polysorbate 80-coated nanoparticles by the brain blood vessel endothelial cells.
Journal ArticleDOI
Significant transport of doxorubicin into the brain with polysorbate 80-coated nanoparticles
A. E. Gulyaev,Svetlana Gelperina,I. N. Skidan,Arkady S. Antropov,Gregory Ya. Kivman,Jörg Kreuter +5 more
TL;DR: It is demonstrated that the brain concentration of systemically administered doxorubicin can be enhanced over 60-fold by binding to biodegradable poly(butyl cyanoacrylate) nanoparticles, overcoated with the nonionic surfactant polysorbate 80.
Journal ArticleDOI
Delivery of loperamide across the blood-brain barrier with polysorbate 80-coated polybutylcyanoacrylate nanoparticles.
TL;DR: Polysorbate 80-coated PBCA nanoparticles loaded with loperamide enabled the transport of loperamia to the brain and induced a much less pronounced and very short analgesia.