Distinct mediating systems for the transport of neutral amino acids by the ehrlich cell
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This article is published in Journal of Biological Chemistry.The article was published on 1963-11-01 and is currently open access. It has received 801 citations till now. The article focuses on the topics: Neutral amino acid transport & Protein metabolism.read more
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Amino acid transport across mammalian intestinal and renal epithelia.
TL;DR: The identification of most epithelial amino acid transporters over the past 15 years allows the definition of these disorders at the molecular level and provides a clear picture of the functional cooperation between transporter in the apical and basolateral membranes of mammalian epithelial cells.
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Blood–Brain Barrier Transport of Kynurenines: Implications for Brain Synthesis and Metabolism
TL;DR: The results demonstrate the saturable transfer of L‐KYN across the blood–brain barrier and suggest that circulating L‐ KYN, 3‐HKYN, and ANA may each contribute significantly to respective cerebral pools under normal conditions.
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Amino acid transporters ASCT2 and LAT1 in cancer: partners in crime?
Bryan C. Fuchs,Barrie P. Bode +1 more
TL;DR: The properties and putative relationship of these two amino acid exchangers are discussed in the context of their demonstrated utility in cancer biology, including cellular growth and survival signaling and integrated links to the mammalian target-of-rapamycin (mTOR) kinase.
Journal Article
Radiolabeled amino acids : Basic aspects and clinical applications in oncology
TL;DR: In brain tumor imaging, the use of radiolabeled amino acids is established, the diagnostic accuracy of amino acid imaging seems adequate, and the diagnostic value seems advantageous, although tumor specificity is not absolute.
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Transport of cationic amino acids by the mouse ecotropic retrovirus receptor
TL;DR: A coincidence in the positions of the first eight putative membrane-spanning domains found in the virus receptor1 and in two related proteins2, the arginine2–4 and histidine2,3,5 permeases of Saccharomyces cerevisiae is reported, but not in any other proteins identified by computer-based sequence comparison of the Gen Bank data base.
References
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Nature of insulin action on amino acid uptake by the isolated diaphragm.
TL;DR: The present study considers the question whether such model amino acids gain access to the diaphragm atypically, and what kind of an entry process insulin modifies.
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Uphill transport induced by counterflow
Thomas Rosenberg,W. Wilbrandt +1 more
TL;DR: It is shown that the flow-induced uphill transport is a feature characteristic for mobile carrier systems only and is not to be expected in systems in which the substrate is bound to a fixed membrane component ("adsorption membrane"), although such a system may yield identical transport kinetics.
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Études cinétiques sur la galactoside-perméase d'Escherichia coli
TL;DR: A model is proposed which is compatible with the observed behaviour of the entry and exit parameters under various conditions, and it is shown that the entry mechanism is catalytic; it is coupled with metabolic energy donors.
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Concentrative uptake of amino acids by the Ehrlich mouse ascites carcinoma cell.
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Potassium migration and amino acid transport.
TL;DR: A finding that glycine accumulation by the Ehrlich mouse ascitcs carcinoma cells falls off precipitously when the extracellular K+ level is kept well below the normal range is investigated.