Does DPP-4 inhibitor treatment affect the clinical outcomes of COVID-19 in type 2 diabetes mellitus patients?
Rumeysa Selvinaz Erol,Esra Şen,Feyza Yener Ozturk,Zeynep Sarac,Gizem Leyla Kokoglu,Muhammed Masum Canat,Duygu Yildiz,Yunus Emre Aytekin,Dilek Yildiz Sevgi,Yuksel Altuntas +9 more
TLDR
It is demonstrated that the use of DPP-4i by patients with T2DM in catching COVID-19 does not affect the mortality due to CO VID-19, the severity of COVID -19 disease, and 3-month post-discharge mortality.Abstract:
OBJECTIVE We aim to investigate whether the use of dipeptidyl peptidase inhibitors (DPP-4i) affects the severity of disease, hospital mortality, and 3-month post-discharge mortality in type 2 diabetes mellitus (T2DM) individuals with coronavirus disease 2019 (COVID-19) infection. METHODS The study included 217 patients with type 2 diabetes hospitalized due to COVID-19 between March and October 2020. The patients included in the study were divided into two groups those using DPP-4i and those not using DPP-4i. Demographic characteristics, laboratory parameters, accompanying risk factors, concomitant comorbidities, hospital mortality, clinical course, and 3-month post-discharge mortality were compared between the patients who used DPP-4i and those who did not use. RESULTS The duration of hospitalization was 10.96±9.16 days in the group using DPP-4i, 12.22±9.1 days in the group not using DPP-4i, and when both groups were evaluated together, it was determined as 11.91±9.11 days. The hospitalization periods were similar between DPP-4i users and non-DPP-4i users (p=0.384). The need for mechanical ventilation (p=0.478 OR 0.710 95% confidence interval [CI], 0.274–1.836) and high-flow nasal cannula (p=0.457, OR: 0.331, 95% CI: 0.41–2.67) were similar between DPP-4i users and non-users. It was determined that the mortality (p=0.208, OR: 0.409, 95% CI: 0.117–1.429) and 3-month post-discharge mortality (p=0.383) were similar in the group using DPP-4i and those not using DPP-4i. CONCLUSION This study demonstrated that the use of DPP-4i by patients with T2DM in catching COVID-19 does not affect the mortality due to COVID-19, the severity of COVID-19 disease, and 3-month post-discharge mortality.read more
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Risk phenotypes of diabetes and association with COVID-19 severity and death: an update of a living systematic review and meta-analysis
Sabrina Schlesinger,Alexander Lang,Nikoletta Christodoulou,Oliver Kuss,Christian Herder,Manuela Neuenschwander,Janett Barbaresko,Michael Roden +7 more
TL;DR: In this article , the authors provide a systematic overview of the current body of evidence on high-risk phenotypes of diabetes associated with COVID-19 severity and death, and a random-effects meta-analysis is used to calculate summary relative risks with 95% CIs.
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Association of metformin, dipeptidyl dipeptidase-4 inhibitors, and insulin with COVID-19-related hospital outcomes in patients with type 2 diabetes
Derrick Obiri-Yeboah,James Bena,Mahmoud Alwakeel,Lauren Buehler,Vinni Makin,Keren Zhou,Kevin M. Pantalone,M. Cecilia Lansang +7 more
TL;DR: In this paper , the effect of metformin, DPP-4 inhibitors (DPP-4i), and insulin on admission to the intensive care unit (ICU), need for assisted ventilation, development of renal insufficiency, and mortality, in patients admitted with COVID-19 infection after controlling for clinical variables and other relevant diabetes-related medications in patients with type 2 DM.
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Role of nutrients in modulating microbiota and immunity in COVID-19 disease.
Laura Di Renzo,P. Gualtieri,Pierluigi Rio,Maria Grazia Massaro,Marina Caldarelli,Giulia Frank,David Della-Morte,Adriano Gasbarrini,Giovanni Gambassi,A De Lorenzo,Laura Franza,Rossella Cianci +11 more
TL;DR: In this paper, the role of nutrients in the relationship between the gut microbiota and the immune response in SARS-CoV-2 infection was discussed, focusing on the benefits offered by vitamins and micronutrients on different aspects of COVID-19 disease while also discussing which diets seem to provide the most advantages.
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