Journal ArticleDOI
Does leukocytospermia associate with poor semen parameters and sperm functions in male infertility? The role of different seminal leukocyte concentrations.
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TLDR
It is suggested that leukocytospermia may have a favorable effect on some sperm functions at seminal leukocyte concentrations between 1 and 3x10(6)/ml.About:
This article is published in European Journal of Obstetrics & Gynecology and Reproductive Biology.The article was published on 2000-04-01. It has received 55 citations till now. The article focuses on the topics: Semen analysis & Acrosome reaction.read more
Citations
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Journal ArticleDOI
Sperm DNA damage caused by oxidative stress: modifiable clinical, lifestyle and nutritional factors in male infertility.
TL;DR: DNA fragmentation is an important factor in the aetiology of male infertility, however it is still underevaluated and its inclusion in routine semen analysis is debated, and sources of oxidative stress should be thoroughly examined in men with high levels of DNA fragmentation and modified where possible.
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Effect of reactive oxygen species produced by spermatozoa and leukocytes on sperm functions in non-leukocytospermic patients
Ralf Henkel,Eva Kierspel,T. Stalf,Claas Mehnert,Roelof Menkveld,Hans-Rudolf Tinneberg,Wolf-Bernhard Schill,Thinus F. Kruger +7 more
TL;DR: The origin of ROS seems to have an influence on the site of the damage in sperm functions, and the threshold given by the World Health Organization (WHO) should be re-evaluated.
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Leukocytes and oxidative stress: dilemma for sperm function and male fertility.
TL;DR: A proper andrological diagnostic work-up, including the evaluation of ROS levels and the antioxidant capacity of the semen, has to be carried out beforehand, aimed at keeping the fine balance between oxidation and scavenging of vital amounts of ROS.
Journal ArticleDOI
Male idiopathic oligoasthenoteratozoospermia
TL;DR: Age, non-inflammatory functional alterations in post-testicular organs, infective agents, alterations in gamete genome, mitochondrial alterations, environmental pollutants and "subtle" hormonal alterations are all considered possible causes of iOAT.
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Influence of reactive oxygen species on human sperm functions and fertilizing capacity including therapeutical approaches
TL;DR: Standardized assessment and evaluation of ROS and total antioxidant capacity in semen should be established to keep ROS in a physiological level and prevent over-treatment of antioxidants toward reductive stress, which should be kept in mind, especially in assisted reproductive procedure.
References
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Cellular basis of defective sperm function and its association with the genesis of reactive oxygen species by human spermatozoa.
TL;DR: Studies with scavengers of reactive oxygen species revealed that, while reagents directed against singlet oxygen and the hydroxyl radical were without effect, cytochrome C reduced the response to A23187 by about 50%, suggesting that the superoxide anion radical is a major product of the activated human spermatozoon.
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Reactive oxygen species and human spermatozoa. I. Effects on the motility of intact spermatozoa and on sperm axonemes.
E. de Lamirande,Claude Gagnon +1 more
TL;DR: The data suggest that ROS induce a chain of events leading to sperm immobilization, that axonemes are affected, and that limited endogenous repair mechanisms exist to reverse these damages.
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Seminal tract infections: impact on male fertility and treatment options
TL;DR: Only recently have amplification methods been established to detect viruses in semen with high sensitivity and specificity, and it is unclear if these infections significantly contribute to male infertility.
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Reactive oxygen species released by activated neutrophils, but not by deficient spermatozoa, are sufficient to affect normal sperm motility.
TL;DR: The production of ROS by deficient spermatozoa is low and of no consequence to the motility of normal spermatozosa present in the same sperm preparation, however, 1 x 10(6) activated PMN/mL, with a 1,000-fold higher ROS production, have detrimental effects on the motilty of normal washed spermarozoa.
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Leukocytospermia is associated with poor semen quality
Hans Wolff,Joseph A. Politch,Adriana Martinez,Florina Haimovici,Joseph A. Hill,Deborah J. Anderson +5 more
TL;DR: In this article, sperm samples from 179 male infertility patients were analyzed for type and number of white blood cells (WBC) by a combination of immunologic techniques and showed that elevated levels of WBC in semen are associated with poor semen quality.