Journal ArticleDOI
Dopamine agonists potentiate antiakinetic effects of competitive NMDA-antagonists in monoamine-depleted mice.
K Kannari,R Markstein +1 more
TLDR
The results indicate that concomitant blockade of NMDA-receptors and activation of dopamine receptors results in synergistic or at least additive motor stimulatory effects.Abstract:
The competitive NMDA-antagonists SDZ EAA-494 and CGP 37849 and the mixed D-1/D-2 dopamine agonists CI 201-678 and SDZ 205-152 reverse akinesia in monoamine-depleted mice in a dose dependent manner. Combination of threshold doses of NMDA-antagonists with dopamine agonists markedly enhances anti-akinetic effects. CI 201-678 which in addition to D-1 and D-2 receptors stimulates alpha-2 receptors produces a stronger effect than SDZ 205-152 which is devoid of alpha-2 agonist activity. The results indicate that concomitant blockade of NMDA-receptors and activation of dopamine receptors results in synergistic or at least additive motor stimulatory effects.read more
Citations
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Glutamate/dopamine D1/D2 balance in the basal ganglia and its relevance to Parkinson' disease
TL;DR: A critical look at the motor characteristics of this new class of drugs in rodent and primate models of parkinsonism and assesses the clinical potential and pitfalls of this radical new approach.
Journal ArticleDOI
Involvement of basal ganglia transmitter systems in movement initiation
TL;DR: Taking together, neurochemical systems of the basal ganglia significantly contribute to intact response initiation by mechanisms which are only partly consistent with predictions of the current functional scheme of theBasal ganglia, suggesting functional differences of the output structures.
Journal ArticleDOI
Behavioural pharmacology of glutamate receptors in the basal ganglia.
TL;DR: Only few data on the role of metabotropic receptors exist but the different receptor subtypes with different regional distribution represent a promising target for pharmacological interventions.
Journal ArticleDOI
Effects of dopamine D1 and D2 receptor blockade on MK-801-induced hyperlocomotion in rats
TL;DR: The locomotor activity induced by MK-801 appears to be less sensitive to dopaminergic receptor blockade than that induced byd-amphetamine, suggesting that the underlying mechanisms, although similar, are not identical.
Journal ArticleDOI
The role of excitatory amino acids in experimental models of Parkinson's disease.
TL;DR: Disturbances in the glutamatergic transmission in various brain structures seem to play a significant role in the development of symptoms of Parkinson's disease.
References
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TL;DR: 'The following abbreviations have been used in the text'; I3-N-uxalyl-L-a,l3diaminu-prupiunic acid; ACPD, Trans-l-aminu-cydupentyl-I,3-dicarbuxylate; AMPA, a aminU-3-hydruxy-5-methyl-isoxazole-4-propionate; AP4, 2-
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Distribution of N-methyl-D-aspartate-sensitive L-[3H]glutamate-binding sites in rat brain
TL;DR: The distribution of NMDA-sensitive L-[3H]glutamate-binding sites suggests that the NMDA receptor represents a major, distinct subset of excitatory amino acid receptors and indicates regions in which neurotransmission may be mediated or modulated by this receptor.
Journal ArticleDOI
The mysterious motor function of the basal ganglia The Robert Wartenberg Lecture
TL;DR: My conclusion is that, as far as evidence goes, the basal ganglia should still be regarded as organs of motor control, and some physiologists and psychologists have speculated that these regions may exert much wider functions in sensory and “cognitive” domains as well as in the motor sphere.
Journal ArticleDOI
Tyrosine hydroxylase-immunoreactive boutons in synaptic contact with identified striatonigral neurons, with particular reference to dendritic spines
TL;DR: It is proposed that the spatial distribution of presumed dopaminergic terminals in synaptic contact with different parts of striatonigral neurons has important functional implications and might alter the pattern of firing of striatal output neurons by regulating their input.
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