Open AccessJournal Article
Drug-induced lysosomal storage disorders
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This article is published in Frontiers of Biology in China.The article was published on 1979-01-01 and is currently open access. It has received 210 citations till now. The article focuses on the topics: Substrate reduction therapy & Lipid metabolism.read more
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A simple quantitative procedure using monolayer cultures for cytotoxicity assays (HTD/NR-90)
TL;DR: A sensitive quantitative procedure for assaying viable cells in monolayer cultures is described, conveniently carried out within the same culture, and standardized for use with 96-well microtiter plates and automatic reading with a Dynatech spectrophotometric microplate reader.
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The use of biomarkers in biomonitoring: a 2-tier approach assessing the level of pollutant-induced stress syndrome in sentinel organisms.
TL;DR: A selection of biomarkers of stress, genotoxicity and exposure usually employed in biomonitoring programmes is presented, together with a brief overview of new biomolecular approaches.
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Cationic Amphiphilic Drug-Induced Phospholipidosis
TL;DR: The phospholipid metabolism, physiochemical characteristics of cationic amphiphilic drugs (CADs), interaction of CADs with biologic membranes and lysosome metabolism, influence of CAD’s onospholipases and phospholIPid synthesis, and a proposed mechanism for induction of phospholipsidosis in the lung are reviewed.
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Cytochemical responses of the lysosomal system and NADPH-ferrihemoprotein reductase in molluscan digestive cells to environmental and experimental exposure to xenobiotics
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Amiodarone Pulmonary Toxicity: Recognition and Pathogenesis (Part I)
TL;DR: As the understanding of the biochemical and cellular mechanisms of APT improve, a number of key clinical issues may be clarified: (1) risk factor assessment for APT, (2) criteria for early diagnosis ofAPT, and (3) improved therapeutic approach to patients with APT.