Journal ArticleDOI
Drug resistance in veterinary helminths
Adrian J. Wolstenholme,Ian Fairweather,Roger K. Prichard,Georg von Samson-Himmelstjerna,Nicholas C. Sangster +4 more
TLDR
Some of the recent findings on resistance mechanisms are summarized, some recommendations for limiting its impact are put forward and some priorities for research in this area are suggested.About:
This article is published in Trends in Parasitology.The article was published on 2004-10-01. It has received 799 citations till now.read more
Citations
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Journal ArticleDOI
The detection of anthelmintic resistance in nematodes of veterinary importance.
Gerald C. Coles,Frank Jackson,W.E. Pomroy,Roger K. Prichard,G. von Samson-Himmelstjerna,A. Silvestre,Mike Taylor,Jozef Vercruysse +7 more
TL;DR: Revised and new methods for the detection of anthelmintic resistance in nematodes of ruminants, horses and pigs are provided here with the purpose that they are evaluated internationally to establish whether they could in the future be recommended by the WAAVP.
Journal ArticleDOI
A new class of anthelmintics effective against drug-resistant nematodes
Ronald Kaminsky,Pierre Ducray,Martin Jung,Ralph Clover,Lucien Rufener,Lucien Rufener,Jacques Bouvier,Sandra Schorderet Weber,Andre Wenger,Susanne Christine Wieland-Berghausen,Thomas Goebel,Noëlle Gauvry,François Pautrat,Thomas Skripsky,Olivier Froelich,Clarisse Komoin-Oka,Bethany Westlund,Ann Sluder,Pascal Mäser +18 more
TL;DR: The discovery of the amino-acetonitrile derivatives (AADs) as a new chemical class of synthetic anthelmintics and the development of drug candidates that are efficacious against various species of livestock-pathogenic nematodes are described.
Book ChapterDOI
Wolbachia bacterial endosymbionts of filarial nematodes.
TL;DR: In this paper, the symbiosis of Wolbachia bacteria with filarial nematodes has been studied and the authors summarized the current understanding of the evolution of the symbiotic association together with insights into the functional basis of the interaction derived from genomic analysis.
Journal ArticleDOI
Prevalence and intensity of Onchocerca volvulus infection and efficacy of ivermectin in endemic communities in Ghana: a two-phase epidemiological study
Mike Y. Osei-Atweneboana,Mike Y. Osei-Atweneboana,J.K.L. Eng,Daniel A. Boakye,John O. Gyapong,Roger K. Prichard +5 more
TL;DR: The results suggest that resistant adult parasite populations, which are not responding as expected to ivermectin, are emerging and a high rate of repopulation of skin with microfilariae will allow parasite transmission.
The Wolbachia bacterial endosymbionts of filarial nematodes.
TL;DR: The contribution of Wolbachia to inflammatory-mediated pathogenesis and adverse reactions to anti-filarial drugs and the outcome of recent field trials using antibiotics as a promising new tool for the treatment of filarial infection and disease are discussed.
References
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Journal ArticleDOI
World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) methods for the detection of anthelmintic resistance in nematodes of veterinary importance.
Gerald C. Coles,Christian Bauer,Fred H.M. Borgsteede,Stanny Geerts,T.R. Klei,M.A. Taylor,P.J. Waller +6 more
TL;DR: Methods have been described to assist in the detection of anthelmintic resistance in strongylid nematode of ruminants, horses and pigs, and an in vitro test, the egg hatch test for detection of benzimidazole resistance in nematodes that hatch shortly after embryonation.
Journal ArticleDOI
One GABA and two acetylcholine receptors function at the C. elegans neuromuscular junction.
TL;DR: It is demonstrated that all three receptor types function at neuromuscular synapses in C. elegans, including a GABA receptor and two acetylcholine receptors.
Journal ArticleDOI
The development of anthelmintic resistance in sheep nematodes.
Frank Jackson,R.L. Coop +1 more
TL;DR: Given that there is little likelihood of a series of novel action compounds emerging in the immediate future to replace this family the conservation of efficacy of the AM group should be accorded the highest priority for research in this area.
Journal Article
Refugia--overlooked as perhaps the most potent factor concerning the development of anthelmintic resistance.
TL;DR: It is suggested that the phenomenon of refugia plays a much more important role in the selection of anthelmintic res istance than other phenomena that are more frequently investigated and recommended for counteracting it, such as reduced drenching frequency and avoiding under-dosing.
Journal ArticleDOI
The genetics of ivermectin resistance in Caenorhabditis elegans
TL;DR: In the nematode Caenorhabditis elegans, simultaneous mutation of three genes, avr-14,Avr-15, and glc-1, encoding glutamate-gated chloride channel (GluCl) alpha-type subunits confers high-level resistance to the antiparasitic drug ivermectin.